High-density comparative BAC mapping in the black muntjac (Muntiacus crinifrons): Molecular cytogenetic dissection of the origin of MCR 1p+4 in the X1X2Y1Y2Y3 sex chromosome system
文献类型：期刊论文
| 作者 | Huang L1,2; Yang FT[*]1,3; Su WT1; Chi JX1; Wang JH1; Nie WH1 |
| 刊名 | GENOMICS
 |
| 出版日期 | 2006 |
| 卷号 | 87期号:5页码:608-615 |
| 关键词 | BAC mapping chromosomal rearrangements Muntiacus crinifrons tandem fusion sex chromosome system |
| 通讯作者 | fy1@sanger.ac.uk |
| 英文摘要 | The black muntjac (Muntiacus crinifrons, 2n = 8 female/9 male) is a critically endangered mammalian species that is confined to a narrow region of southeastern China. Male black muntjacs have an astonishing X1X2Y1Y2Y3 sex chromosome system, unparalleled in eutherian mammals, involving approximately half of the entire genome. A high-resolution comparative map between the black muntjac (M. crinifrons) and the Chinese muntjac (M. reevesi, 2n = 46) has been constructed based on the chromosomal localization of 304 clones from a genomic BAC (bacterial artificial chromosome) library of the Indian muntjac (M. muntjak vaginalis, 2n = 6 female/7 male). In addition to validating the chromosomal homologies between M. reevesi and M. crinifrons defined previously by chromosome painting, the comparative BAC map demonstrates that all tandem fusions that have occurred in the karyotypic evolution of M. crinifrons are centromere-telomere fusions. The map also allows for a more detailed reconstruction of the chromosomal rearrangements leading to this unique and complex sex chromosome system. Furthermore, we have identified 46 BAC clones that could be used to study the molecular evolution of the unique sex chromosomes of the male black muntjacs. |
| 收录类别 | SCI |
| 资助信息 | This research was supported by the National Natural Science Foundation of China (No. 30170506) and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10881]  |
| 专题 | 昆明动物研究所_保护遗传学(细胞库) 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People's Republic of China 2.The Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China 3.Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK |
| 推荐引用方式 GB/T 7714 | Huang L,Yang FT[*],Su WT,et al. High-density comparative BAC mapping in the black muntjac (Muntiacus crinifrons): Molecular cytogenetic dissection of the origin of MCR 1p+4 in the X1X2Y1Y2Y3 sex chromosome system[J]. GENOMICS,2006,87(5):608-615. |
| APA | Huang L,Yang FT[*],Su WT,Chi JX,Wang JH,&Nie WH.(2006).High-density comparative BAC mapping in the black muntjac (Muntiacus crinifrons): Molecular cytogenetic dissection of the origin of MCR 1p+4 in the X1X2Y1Y2Y3 sex chromosome system.GENOMICS,87(5),608-615. |
| MLA | Huang L,et al."High-density comparative BAC mapping in the black muntjac (Muntiacus crinifrons): Molecular cytogenetic dissection of the origin of MCR 1p+4 in the X1X2Y1Y2Y3 sex chromosome system".GENOMICS 87.5(2006):608-615. |
入库方式： OAI收割
来源：昆明动物研究所
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