Detecting lineage-specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup
文献类型：期刊论文
| 作者 | Yu XJ1,2,3; Zheng HK4,5; Wang J4,5,6; Wang W1; Su B[*]1,2 |
| 刊名 | GENOMICS
 |
| 出版日期 | 2006 |
| 卷号 | 88期号:6页码:745-751 |
| 关键词 | Positive selection Adaptive evolution Brain-expressed gene Hominoids |
| ISSN号 | 0888-7543 |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Comparative genetic analysis between human and chimpanzee may detect genetic divergences responsible for human-specific characteristics. Previous studies have identified a series of genes that potentially underwent Darwinian positive selection during human evolution. However, without a closely related species as outgroup, it is difficult to identify human-lineage-specific changes, which is critical in delineating the biological uniqueness of humans. In this study, we conducted phylogeny-based analyses of 2633 human brain-expressed genes using rhesus macaque as the outgroup. We identified 47 candidate genes showing strong evidence of positive selection in the human lineage. Genes with maximal expression in the brain showed a higher evolutionary rate in human than in chimpanzee. We observed that many immune-defense-related genes were under strong positive selection, and this trend was more prominent in chimpanzee than in human. We also demonstrated that rhesus macaque performed much better than mouse as an outgroup in identifying lineage-specific selection in humans. |
| 收录类别 | SCI |
| 资助信息 | ThisstudywassupportedbygrantsfromtheChinese Academy of Sciences (KSCX2-SW-121), the National Natural ScienceFoundationofChina(30370755,30440018,30525028), the Natural Science Foundation of Yunnan Province of China, and the National 973 Project of China (2006CB701506). |
| 原文出处 | 200688745.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2141]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_基因起源组 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Graduate School, Chinese Academy of Sciences, Beijing, China 4.Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China 5.The Institute of Human Genetics, University of Aarhus, DK-8000 Aarhus C, Denmark 6.Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense M, Denmark |
| 推荐引用方式 GB/T 7714 | Yu XJ,Zheng HK,Wang J,et al. Detecting lineage-specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup[J]. GENOMICS,2006,88(6):745-751. |
| APA | Yu XJ,Zheng HK,Wang J,Wang W,&Su B[*].(2006).Detecting lineage-specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup.GENOMICS,88(6),745-751. |
| MLA | Yu XJ,et al."Detecting lineage-specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup".GENOMICS 88.6(2006):745-751. |
入库方式： OAI收割
来源：昆明动物研究所
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