Rapid evolution, genetic variations, and functional association of the human spermatogenesis-related gene NYD-SP12
文献类型：期刊论文
| 作者 | Zhang Q1,2; Zhang F3; Chen XH1,2; Wang YQ1,2; Wang WQ4; Alice AL5; Jin L3; Huo R6; Sha JH6; Li Z7 |
| 刊名 | JOURNAL OF MOLECULAR EVOLUTION
 |
| 出版日期 | 2007 |
| 卷号 | 65期号:2页码:154-161 |
| 关键词 | Genetic variations Darwinian posi- tive selectio Spermatogenesis Sexual selection Human evolution |
| ISSN号 | 0022-2844 |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | NYD-SP12 is a recently identified spermatogenesis-related gene with a pivotal role in human testis development. In this study, we analyzed between-species divergence and within-species variation of NYD-SP12 in seven representative primate species, four worldwide human populations, and 124 human clinical subjects. Our results indicate that NYD-SP12 evolves rapidly in both the human and the chimpanzee lineages, which is likely caused by Darwinian positive selection and/or sexual selection. We observed significant interpopulation divergence among human populations, which might be due to the varied demographic histories. In the association analysis, we demonstrated significant frequency discrepancy of a synonymous sequence polymorphism among the clinical groups with different sperm traits. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the Chinese Academy of Sciences (KSCX1-YW-R-34), the National Natural Science Foundation of China (30370755, 30525028, 30630013), the Natural Science Foundation of Yunnan Province of China, and the National 973 Project of China (2006CB701506). |
| 原文出处 | 200765154.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2155]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China 3.State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai, China 4.Department of Pathology, Third Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, Chin 5.Department of Genetics, Stanford University, Stanford, California, USA 6.Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China 7.Renji Hospital, Shanghai Second Medical University, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Zhang Q,Zhang F,Chen XH,et al. Rapid evolution, genetic variations, and functional association of the human spermatogenesis-related gene NYD-SP12[J]. JOURNAL OF MOLECULAR EVOLUTION,2007,65(2):154-161. |
| APA | Zhang Q.,Zhang F.,Chen XH.,Wang YQ.,Wang WQ.,...&Su B[*].(2007).Rapid evolution, genetic variations, and functional association of the human spermatogenesis-related gene NYD-SP12.JOURNAL OF MOLECULAR EVOLUTION,65(2),154-161. |
| MLA | Zhang Q,et al."Rapid evolution, genetic variations, and functional association of the human spermatogenesis-related gene NYD-SP12".JOURNAL OF MOLECULAR EVOLUTION 65.2(2007):154-161. |
入库方式： OAI收割
来源：昆明动物研究所
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