Molecular evolution of a primate-specific microRNA family
文献类型：期刊论文
| 作者 | Zhang R1,2,3; Wang YQ1,2; Su B[*]1,2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2008 |
| 卷号 | 25期号:7页码:1493-1502 |
| 关键词 | microRNA birth-and-death evolution Alu primates |
| ISSN号 | 0737-4038 |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Lineage-specific microRNA (miRNA) families may contribute to developmental novelties during evolution. However, little is known about the origin and evolution of new miRNA families. We report evidence of an Alu-mediated rapid expansion of miRNA genes in a previously identified primate-specific miRNA family, drawn from sequencing and comparative analysis of 9 diverse primate species. Evolutionary analysis reveals similar divergence among miRNA copies whether they are within or between species, lineage-specific gain and loss of miRNAs, and gene pseudolization in multiple species. These observations support a birth-and-death process of miRNA genes in this family, implicating functional diversification during primate evolution. In addition, both secondary structure conservation and reduced single nucleotide polymorphisms density attest to functional constraint of this family in primates. Finally, we observed preferential expression of miRNAs in human placenta and fetal brain, suggesting a functional importance of this family for primate development. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the National 973 project of China (2007CB947701, 2007CB815705), the CAS (KSCX1-YW- R-34), the National Natural Science Foundation of China (30525028,30630013,and30623007),andtheNaturalSci- ence Foundation of Yunnan Province of China. |
| 原文出处 | 2008251493.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2175]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, China 3.Graduate School of Chinese Academy Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Zhang R,Wang YQ,Su B[*]. Molecular evolution of a primate-specific microRNA family[J]. MOLECULAR BIOLOGY AND EVOLUTION,2008,25(7):1493-1502. |
| APA | Zhang R,Wang YQ,&Su B[*].(2008).Molecular evolution of a primate-specific microRNA family.MOLECULAR BIOLOGY AND EVOLUTION,25(7),1493-1502. |
| MLA | Zhang R,et al."Molecular evolution of a primate-specific microRNA family".MOLECULAR BIOLOGY AND EVOLUTION 25.7(2008):1493-1502. |
入库方式： OAI收割
来源：昆明动物研究所
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