Contrast features of CpG islands in the promoter and other regions in the dog genome
文献类型：期刊论文
| 作者 | Han L1,2,3; Zhao ZM[*]1,4,5 |
| 刊名 | GENOMICS
 |
| 出版日期 | 2009 |
| 卷号 | 94期号:2页码:117-124 |
| ISSN号 | 0888-7543 |
| 关键词 | CpG islands Dog Promoter Homologous genes Domestication Gene Ontology Genome evolution Essential genes Housekeeping genes |
| 通讯作者 | zzhao@vcu.edu |
| 合作状况 | 其它 |
| 英文摘要 | The recent release of the domestic dog genome provides us with an ideal opportunity to investigate dog-specific genomic features. In this study, we performed a systematic analysis of CpG islands (CGIs), which are often considered gene markers, in the dog genome. Relative to the human and mouse genomes, the dog genome has a remarkably large number of CGIs and high CGI density, which is contributed by its noncoding sequences. Surprisingly, the dog genome has fewer CGIs associated with the promoter regions of genes than the human or the mouse. Further examination of functional features of dog-human-mouse homologous genes suggests that the dog might have undergone a faster erosion rate of promoter-associated CGIs than the human or mouse. Some genetic or genomic factors such as local recombination rate and karyotype may be related to the unique clog CGI features. |
| 收录类别 | SCI |
| 原文出处 | 2009942117.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2183]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Graduate School, Chinese Academy of Sciences, Beijing 100039, China 4.Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 5.Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284, USA |
| 推荐引用方式 GB/T 7714 | Han L,Zhao ZM[*]. Contrast features of CpG islands in the promoter and other regions in the dog genome[J]. GENOMICS,2009,94(2):117-124. |
| APA | Han L,&Zhao ZM[*].(2009).Contrast features of CpG islands in the promoter and other regions in the dog genome.GENOMICS,94(2),117-124. |
| MLA | Han L,et al."Contrast features of CpG islands in the promoter and other regions in the dog genome".GENOMICS 94.2(2009):117-124. |
入库方式： OAI收割
来源：昆明动物研究所
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