Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia
文献类型：期刊论文
| 作者 | Shi H1; Tan SJ2; Zhong H3; Hu WW4; Levine A4; Xiao CJ2; Peng Y1; Qi XB1; Shou WH2; Ma RLZ3 |
| 刊名 | AMERICAN JOURNAL OF HUMAN GENETICS
 |
| 出版日期 | 2009 |
| 卷号 | 84期号:4页码:534-541 |
| ISSN号 | 0002-9297 |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in a cohort of 4029 individuals across Eastern Asia that suggests causative selection. Moreover, the two polymorphisms are not coselected. Haplotype-based selection analysis further suggests that this is a striking example of two functional polymorphisms being strongly selected for in human populations in response to environmental stresses. |
| 收录类别 | SCI |
| 资助信息 | This project was supported by the National 973 project of China (2006CB701506, 2007CB815705), the CAS/SAFEA International Partnership Program for Creative Research Team, Chinese Academy of Sciences (KSCX1-YW-R-34), the National Natural Science Foundation of China (30700445, 30630013, and 30525028), the Natural Science Foundation of Yunnan Province of China, and the Ludwig Institute for Cancer Research. |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2185]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming 650223, PR China 2.Human Genetics Centre, Yunnan University, Kunming 650091, PR China 3.Institute of Genetics and Develop- mental Biology, Chinese Academy of Sciences, Beijing 100101, PR China 4.Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08540, USA 5.Qujing Normal College, Qujing, Yunnan 655011, PR China 6.Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK |
| 推荐引用方式 GB/T 7714 | Shi H,Tan SJ,Zhong H,et al. Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2009,84(4):534-541. |
| APA | Shi H.,Tan SJ.,Zhong H.,Hu WW.,Levine A.,...&Lu X.(2009).Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia.AMERICAN JOURNAL OF HUMAN GENETICS,84(4),534-541. |
| MLA | Shi H,et al."Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia".AMERICAN JOURNAL OF HUMAN GENETICS 84.4(2009):534-541. |
入库方式： OAI收割
来源：昆明动物研究所
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