Adaptive evolution of primate TRIM5 alpha, a gene restricting HIV-1 infection
文献类型：期刊论文
| 作者 | Liu HF1,3,4; Wang YQ1,2,4; Liao CH1,2,4; Kuang YQ1,3,4; Zheng YT[*]1,3; Su B[*]1,2 |
| 刊名 | GENE
 |
| 出版日期 | 2005 |
| 卷号 | 362期号:X页码:109-116 |
| 关键词 | TRIM5 alpha primate Darwinian positive selection HIV-1 restriction |
| ISSN号 | 0378-1119 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Recent studies showed that nonhuman primate TRIM5 alpha can efficiently block HIV-1 infection in human cell lines. It can also restrict other retroviruses, therefore, suggested as a general defender against retrovirus infection. Here, we present an evolutionary analysis of TRIM5 alpha in primates. Our results demonstrated that TRIM5a has been evolving rapidly in primates, which is likely caused by Darwinian positive selection. The SPRY domain of TRM5 alpha, which may be responsible for recognition of incoming viral capsids showed higher nonsynonymous/synonymous substitution ratios than the non-SPRY domain, indicating that the adaptive evolution of TRIM5a ill primates might be an innate strategy developed in defending retrovirus infection during primate evolution. In addition, the comparative protein sequence analysis suggested that the amino acid substitution pattern at a single site (344R/Q/P) located in the SPRY domain may explain the differences in Susceptibilities of HIV-1 infection in diverse primate species. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grant from the Chinese Academy of Sciences (KSCX2-SW-121; KSCX2-SW-216; KSCX1-SW-11), the National Natural Science Foundation of China (30370755; 30471605) and the Natural Science Foundation of Yunnan Province of China. Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), and National 863 Program (2003AA219142). |
| 原文出处 | 2005362109.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4535]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, Chin 2.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoolgy, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoolgy, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Graduate School of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Liu HF,Wang YQ,Liao CH,et al. Adaptive evolution of primate TRIM5 alpha, a gene restricting HIV-1 infection[J]. GENE,2005,362(X):109-116. |
| APA | Liu HF,Wang YQ,Liao CH,Kuang YQ,Zheng YT[*],&Su B[*].(2005).Adaptive evolution of primate TRIM5 alpha, a gene restricting HIV-1 infection.GENE,362(X),109-116. |
| MLA | Liu HF,et al."Adaptive evolution of primate TRIM5 alpha, a gene restricting HIV-1 infection".GENE 362.X(2005):109-116. |
入库方式： OAI收割
来源：昆明动物研究所
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