Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup
文献类型：期刊论文
| 作者 | Yu HJ1,2; Jiang HF2,4; Zhou Q2,4; Yang JF1; Cun Y1; Su B2,3; Xiao CJ[*]1; Wang W[*]2,3 |
| 刊名 | HUMAN MOLECULAR GENETICS
 |
| 出版日期 | 2006 |
| 卷号 | 15期号:11页码:1870-1875 |
| ISSN号 | 0964-6906 |
| 通讯作者 | cjxiao2005@yahoo.com.cn ; wwang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A transmembrane protein gene, c1orf37-dup, was identified as a young gene specific to humans. It was derived from the conserved c1orf37 gene through retroposition after the divergence of human and chimpanzee. This gene has evolved rapidly driven by positive Darwinian selection as evident from a significantly high ratio of non-synonymous substitution rate to synonymous substitution rate (K(a)/K(s)=2.08) between the new c1orf37-dup and the parental c1orf37 genes. Population genetics analysis disclosed a very low level of polymorphism in the c1orf37-dup gene and its neighboring regions, thus providing support for the occurrence of a recent selective sweep. The GFP experiments revealed that it encodes a transmembrane protein associated with cell membranes. Non-random distribution of amino acid changes indicates the C1ORF37-DUP protein may have evolved diverged functions in the presumably functionally important N-terminal region in the cytoplasm and the extracellular loop. These lines of evidence support that the functional adaptation of c1orf37-dup has occurred in humans. Unlike its ubiquitously expressed parental gene, c1orf37-dup expresses selectively in several human tissues including brain. It is suggested that c1orf37-dup encodes a novel transmembrane protein in humans which potentially endows new properties to cell surface interactions. |
| 收录类别 | SCI |
| 资助信息 | This project was supported by the Key Project KSCX2-SW-121 from Chinese Academy of Sciences to W.W. and B.S., the Science and Technology Key Project 2005NG08 from Yunnan Province and the Western Chinese Region Develop- ment Key Project 2004BA901A07 to C.X. and the grant 30560063 from National Science Foundation of China to H.Y. |
| 原文出处 | 2006151870.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4819]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Bioresources Conservation and Utilization and Human Genetics Center of Yunnan University, Kunming 650091, PR China 2.CAS-Max Planck Junior Research Group and Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology 3.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming 650223, PR China 4.Graduate School of Chinese Academy Sciences, Beijing 100039, PR China |
| 推荐引用方式 GB/T 7714 | Yu HJ,Jiang HF,Zhou Q,et al. Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup[J]. HUMAN MOLECULAR GENETICS,2006,15(11):1870-1875. |
| APA | Yu HJ.,Jiang HF.,Zhou Q.,Yang JF.,Cun Y.,...&Wang W[*].(2006).Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.HUMAN MOLECULAR GENETICS,15(11),1870-1875. |
| MLA | Yu HJ,et al."Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup".HUMAN MOLECULAR GENETICS 15.11(2006):1870-1875. |
入库方式： OAI收割
来源：昆明动物研究所
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