Distribution of CCR2-64I and SDF1-3 ' A alleles and HIV status in 7 ethnic populations of Cameroon
文献类型：期刊论文
| 作者 | Ma LY1,2; Marmor M3,8; Zhong P1,5; Ewane L6; Su B4,7; Nyambi P[*]1,8,9 |
| 刊名 | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
 |
| 出版日期 | 2005 |
| 卷号 | 40期号:1页码:89-95 |
| 关键词 | CCR2-64I SDF1-3 ' A CCR5D32 allelic frequency |
| 通讯作者 | phillipe.nyambi@ med.nyu.edu |
| 合作状况 | 其它 |
| 英文摘要 | Limited information is available on the prevalence among rural Africans of host genetic polymorphisms conferring resistance to HIV-1 infection or slowing HIV disease progression. We report the allelic frequencies of the AIDS-related polymorphisms CCR2-64I, SDF1-3'A, and CCR5-Delta 32 in 321 volunteers from 7 ethnic groups in Cameroon. Allelic frequencies differed among the 7 ethnic groups, ranging from 10.8% to 31.3% for CCR2-641 and 0.0% to 7.1% for SDF1-3'A. No CCR5-Delta 32 alleles were found. HIV seroprevalence was 6.9% in the total population and peaked at younger ages in girls and women than in boys and men. Among 15- to 54-year-olds, HIV seroprevalence varied from 2.0% to 11.1% among the village populations. Conditional logistic regression analysis using data from boys and men aged 15 to 54 years showed the number of CCR2-641 alleles to be a significant risk factor for HIV seropositivity (odds ratio per allele adjusted for age and matched on ethnic group = 6.3, 95% confidence interval: 1.3-30.3);, this association was not found in women. The findings are consistent with the hypothesis that CCR2-641 alleles may delay HIV disease progression without affecting susceptibility to infection among men. We did not observe this relation among women, and other factors, such as multiple pregnancies or maternal stressors (eg, breastfeeding), may have masked any protective effect of CCR2-641 alleles. Further study of this issue among women is warranted. SDF1-3'A did not differ between HIV seropositive and HIV seronegative individuals associated with increasing age among HIV-seronegative women, suggesting a protective effect against HIV-1 infection. |
| 收录类别 | SCI |
| 资助信息 | Supported in part by grants from the National Institutes of Health (AI47053, AI36085, AI27742 and HL59725) and the Fogarty International Center (TW01254 and TW01409) and by funds from the Department of Veterans Affairs (Merit Review Award and the Research Enhancement Program). |
| 语种 | 英语 |
| 公开日期 | 2010-08-27 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6046]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Department of Pathology, New York University School of Medicine, New York, NY 2.National Center for AIDS/STD Prevention and Control, China Center for Disease Control and Prevention, Beijing, China 3.Department of Environmental Medicine and Medicine, New York University School of Medicine, New York, NY 4.Center for Genome Information, University of Cincinnati, Cincinnati, OH 5.Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China 6.Laboratoire de Sante ´ Hygiene Mobile, Yaounde, Cameroon 7.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 8.Center for AIDS Research, New York University School of Medicine, New York, NY 9.Research Enhancement Award Program, Veterans Affairs Medical Center, New York, NY |
| 推荐引用方式 GB/T 7714 | Ma LY,Marmor M,Zhong P,et al. Distribution of CCR2-64I and SDF1-3 ' A alleles and HIV status in 7 ethnic populations of Cameroon[J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,2005,40(1):89-95. |
| APA | Ma LY,Marmor M,Zhong P,Ewane L,Su B,&Nyambi P[*].(2005).Distribution of CCR2-64I and SDF1-3 ' A alleles and HIV status in 7 ethnic populations of Cameroon.JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,40(1),89-95. |
| MLA | Ma LY,et al."Distribution of CCR2-64I and SDF1-3 ' A alleles and HIV status in 7 ethnic populations of Cameroon".JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 40.1(2005):89-95. |
入库方式： OAI收割
来源：昆明动物研究所
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