Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas
文献类型：期刊论文
| 作者 | Peng Y1,2; Yang ZH1,2; Zhang H1; Cui CY3; Qi XB1; Luo XJ1; Tao X4; Wu TY4; Shi H[*]1; Su B[*]1 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2011 |
| 卷号 | 28期号:2页码:1075-1081 |
| 关键词 | adaptive evolution high altitude genetic variation Tibetan natural selection |
| 通讯作者 | shihong@mail.kiz.ac.cn ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Modern humans have occupied almost all possible environments globally since exiting Africa about 100,000 years ago. Both behavioral and biological adaptations have contributed to their success in surviving the rigors of climatic extremes, including cold, strong ultraviolet radiation, and high altitude. Among these environmental stresses, high-altitude hypoxia is the only condition in which traditional technology is incapable of mediating its effects. Inhabiting at >3,000-m high plateau, the Tibetan population provides a widely studied example of high-altitude adaptation. Yet, the genetic mechanisms underpinning long-term survival in this environmental extreme remain unknown. We performed an analysis of genome-wide sequence variations in Tibetans. In combination with the reported data, we identified strong signals of selective sweep in two hypoxia-related genes, EPAS1 and EGLN1. For these two genes, Tibetans show unusually high divergence from the non-Tibetan lowlanders (Han Chinese and Japanese) and possess high frequencies of many linked sequence variations as reflected by the Tibetan-specific haplotypes. Further analysis in seven Tibetan populations (1,334 individuals) indicates the prevalence of selective sweep across the Himalayan region. The observed indicators of natural selection on EPAS1 and EGLN1 suggest that during the long-term occupation of high-altitude areas, the functional sequence variations for acquiring biological adaptation to high-altitude hypoxia have been enriched in Tibetan populations. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the National 973 project of China (2007CB947701, 2007CB815705), the Chinese Academy of Sciences (KSCX1- YW-R-34, Westlight Doctoral Program), the National Natural Science Foundation of China (30700445, 30630013 and 30771181), the State Key Laboratory of Genetic Resources and Evolution (GREKF09-03 and GREKF10-02), and the Natural Science Foundation of Yunnan Province of China (2007C100M, 2009CD107, and 2010CI44). |
| 语种 | 英语 |
| 公开日期 | 2011-03-15 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6583]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_神经系统疾病 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, China 2.Graduate School of Chinese Academy Sciences, Beijing, China 3.School of Medicine, Tibetan University, Lhasa, China 4.National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining, China 5.People’s Hospital of Dangxiong County, Dangxiong, China 6.Department of Genetics, Harvard Medical School, Boston, Massachusetts |
| 推荐引用方式 GB/T 7714 | Peng Y,Yang ZH,Zhang H,et al. Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas[J]. MOLECULAR BIOLOGY AND EVOLUTION,2011,28(2):1075-1081. |
| APA | Peng Y.,Yang ZH.,Zhang H.,Cui CY.,Qi XB.,...&Chen H.(2011).Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas.MOLECULAR BIOLOGY AND EVOLUTION,28(2),1075-1081. |
| MLA | Peng Y,et al."Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas".MOLECULAR BIOLOGY AND EVOLUTION 28.2(2011):1075-1081. |
入库方式： OAI收割
来源：昆明动物研究所
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