Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque
文献类型：期刊论文
| 作者 | Fang XD1; Zhang YF2,3; Zhang R2,4; Yang LX2,3; Li M2,3; Ye KX2; Guo XS1; Wang J[*]1; Su B[*]2 |
| 刊名 | GENOME BIOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 12期号:7页码:R63 |
| 通讯作者 | wangj@genomics.org.cn ; wwang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Rhesus macaque (Macaca mulatta) is the most widely used nonhuman primate animal in biomedical research. A global map of genetic variations in rhesus macaque is valuable for both evolutionary and functional studies. Results: Using next-generation sequencing technology, we sequenced a Chinese rhesus macaque genome with 11.56-fold coverage. In total, 96% of the reference Indian macaque genome was covered by at least one read, and we identified 2.56 million homozygous and 2.94 million heterozygous SNPs. We also detected a total of 125,150 structural variations, of which 123,610 were deletions with a median length of 184 bp (ranging from 25 bp to 10 kb); 63% of these deletions were located in intergenic regions and 35% in intronic regions. We further annotated 5,187 and 962 nonsynonymous SNPs to the macaque orthologs of human disease and drug-target genes, respectively. Finally, we set up a genome-wide genetic variation database with the use of Gbrowse. Conclusions: Genome sequencing and construction of a global sequence variation map in Chinese rhesus macaque with the concomitant database provide applicable resources for evolutionary and biomedical research. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National 973 project of China (2011CBA01101) and the National Natural Science Foundation of China (30871343). |
| 语种 | 英语 |
| 公开日期 | 2011-12-12 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6836]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_转化基因组 |
| 作者单位 | 1.Beijing Genomics Institute-Shenzhen, Chinese Academy of Sciences, Shenzhen 518083, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Center, Chinese Academy of Sciences, Kunming 650223, China 3.Graduate School of Chinese Academy of Sciences, Beijing 100039, China 4.Current address: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China |
| 推荐引用方式 GB/T 7714 | Fang XD,Zhang YF,Zhang R,et al. Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque[J]. GENOME BIOLOGY,2011,12(7):R63. |
| APA | Fang XD.,Zhang YF.,Zhang R.,Yang LX.,Li M.,...&Su B[*].(2011).Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque.GENOME BIOLOGY,12(7),R63. |
| MLA | Fang XD,et al."Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque".GENOME BIOLOGY 12.7(2011):R63. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。