Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia
文献类型：期刊论文
| 作者 | Li M; Luo XJ; Xiao X; Shi L; Liu XY; Yin LD; Diao HB; Su B[*] |
| 刊名 | AMERICAN JOURNAL OF PSYCHIATRY
 |
| 出版日期 | 2011 |
| 卷号 | 168期号:12页码:1318-1325 |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 英文摘要 | Objective: ZNF804A is a schizophrenia risk gene that was recently identified by genome-wide association studies as well as subsequent replications. Although the results are consistent among studies in European populations, there have been conflicting reports in Chinese populations. The authors conducted both association and functional analyses to test whether ZNF804A is a risk gene for schizophrenia in Chinese populations. Method: The authors recruited two case-control samples of independent Han Chinese (a total of 2,207 participants) from southwestern China. A total of six single-nucleotide polymorphisms (SNPs), including the key SNP (rs1344706) that showed significant association with schizophrenia in European populations and the other five promoter SNPs of ZNF804A, were tested. Based on the results of the association analysis, the authors performed two functional assays to test the impact of the risk SNP on transcriptional factor binding affinity and promoter activity. Results: The SNP rs1344706 was not associated with schizophrenia in either of the two Han Chinese groups, and this result was confirmed by meta-analyses in five Han Chinese samples. However, the authors identified two ZNF804A promoter SNPs that were significantly associated with schizophrenia in both samples, and the significance was strengthened in the combined samples and further supported by haplotype analysis. The functional assays demonstrated that the risk SNP (rs359895) can influence Sp1 binding affinity, resulting in a higher promoter activity of the risk allele. Conclusions: Our results suggest that ZNF804A is a common risk gene for schizophrenia in world populations and that the newly identified functional SNP (rs359895) is likely a risk SNP for schizophrenia |
| 收录类别 | SCI |
| 资助信息 | Supported by National 973 Project of China grants 2011CBA00401 and 2007CB947701, National Natural Science Foundation of China grants 30871343 and 31071101, and Natural Science Foundation of Yunnan Province of China grants 2007C100M and 2009CD107. |
| 语种 | 英语 |
| 公开日期 | 2012-02-09 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6855]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_神经系统疾病 昆明动物研究所_转化基因组 |
| 作者单位 | State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, China. |
| 推荐引用方式 GB/T 7714 | Li M,Luo XJ,Xiao X,et al. Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia[J]. AMERICAN JOURNAL OF PSYCHIATRY,2011,168(12):1318-1325. |
| APA | Li M.,Luo XJ.,Xiao X.,Shi L.,Liu XY.,...&Su B[*].(2011).Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia.AMERICAN JOURNAL OF PSYCHIATRY,168(12),1318-1325. |
| MLA | Li M,et al."Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia".AMERICAN JOURNAL OF PSYCHIATRY 168.12(2011):1318-1325. |
入库方式： OAI收割
来源：昆明动物研究所
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