Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population
文献类型：期刊论文
| 作者 | Zhong H1,4; Li XL[*]2,3; Li M1,5; Hao LX2,3; Chen RW2,3; Xiang K1,5; Qi XB1; Ma RLZ[*]4; Su B[*]1 |
| 刊名 | ARTHRITIS RESEARCH & THERAPY
 |
| 出版日期 | 2012 |
| 卷号 | 13期号:6页码:R186 |
| 通讯作者 | xlnli@yahoo.com ; rlma@genetics.ac.cn ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Introduction: Recent genome-wide and candidate gene association studies in large numbers of systemic lupus erythematosus (SLE) patients have suggested approximately 30 susceptibility genes. These genes are involved in three types of biological processes, including immune complex processing, toll-like receptor function and type I interferon production, and immune signal transduction in lymphocytes, and they may contribute to the pathogenesis of SLE. To better understand the genetic risk factors of SLE, we investigated the associations of seven SLE susceptibility genes in a Chinese population, including FCGR3A, FCGR2A, TNFAIP3, TLR9, TREX1, ETS1 and TNIP1. Methods: A total of 20 SNPs spanning the seven SLE susceptibility genes were genotyped in a sample of 564 unrelated SLE patients and 504 unrelated healthy controls recruited from Yunnan, southwestern China. The associations of SNPs with SLE were assessed by statistical analysis. Results: Five SNPs in two genes (TNFAIP3 and ETS1) were significantly associated with SLE (corrected P values ranging from 0.03 to 5.5 x 10(-7)). Through stratified analysis, TNFAIP3 and ETS1 showed significant associations with multiple SLE subphenotypes (such as malar rash, arthritis, hematologic disorder and antinuclear antibody) while TNIP1 just showed relatively weak association with onset age. The associations of the SNPs in the other four genes were not replicated. Conclusions: The replication analysis indicates that TNFAIP3, ETS1 and TNIP1 are probably common susceptibility genes for SLE in Chinese populations, and they may contribute to the pathogenesis of multiple SLE subphenotypes |
| 收录类别 | SCI |
| 资助信息 | The study was supported by the extramural project of State Key Laboratory of Genetic Resources and Evolution (GREKF08-05), the National Natural Science Foundation of China (81060251), the joint project of Yunnan Provincial Department of Science & Technology and Kunming Medical University (2008CD024), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX1-YW-R-45). |
| 语种 | 英语 |
| 公开日期 | 2012-04-05 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6905]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_转化基因组 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Department of Dermatology and Rheumatology, The Affiliated Yan’an Hospital of Kunming Medical University, Kunming, Yunnan 650051, China 3.Kunming Medical University, Kunming, Yunnan 650500, China 4.State Key Zhong et al. Arthritis Research & Therapy 2011, 13:R186 http://arthritis-research.com/content/13/6/R186 Page 7 of 9 Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. 5.Graduate School of Chinese Academy of Sciences, Beijing 100080, China |
| 推荐引用方式 GB/T 7714 | Zhong H,Li XL[*],Li M,et al. Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population[J]. ARTHRITIS RESEARCH & THERAPY,2012,13(6):R186. |
| APA | Zhong H.,Li XL[*].,Li M.,Hao LX.,Chen RW.,...&Su B[*].(2012).Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population.ARTHRITIS RESEARCH & THERAPY,13(6),R186. |
| MLA | Zhong H,et al."Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population".ARTHRITIS RESEARCH & THERAPY 13.6(2012):R186. |
入库方式： OAI收割
来源：昆明动物研究所
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