Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
文献类型：期刊论文
| 作者 | Li M1,16; Wang Y1,16; Zheng XB2; Ikeda M3; Iwata N3; Luo XJ1; Chong SA4; Lee J4; Rietschel M5,6; Zhang FY7 |
| 刊名 | SCHIZOPHRENIA RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 142期号:1-3页码:200-205 |
| 关键词 | VRK2 Schizophrenia Asian populations MRI Brain imaging analysis |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17x10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National 973 project of China (grantnum- ber, 2011CBA00401), the National Natural Science Foundation of China (31237068), the National Medical Research Council Translational and Clinical Research Flagship Program (grant number, NMRC/TCR/003/2008), the German Federal Ministry of Education and Re- search (BMBF), within the context of the National Genome Research Network (NGFN), and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to S.C, grant 01GS08147 to M.R.). Recruitment of the Australian BDP sample was supported by the Australian NHMRC program (grant number 510135). |
| 语种 | 英语 |
| WOS记录号 | WOS:000311220900030 |
| 公开日期 | 2013-04-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7301]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_神经系统疾病 昆明动物研究所_转化基因组 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 3.Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan 4.Institute of Mental Health, Singapore 5.Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, D-68159 Mannheim, Germany 6.Department of Psychiatry, University of Bonn, D-53127 Bonn, Germany 7.Genes, Cognition and Psychosis Program, National Institute of Mental Health, the National Institutes of Health, Bethesda, MD, USA 8.Max Planck Institute of Psychiatry, D-80804 Munich, Germany 9.Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, D-52425 Juelich, Germany 10.Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany |
| 推荐引用方式 GB/T 7714 | Li M,Wang Y,Zheng XB,et al. Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility[J]. SCHIZOPHRENIA RESEARCH,2012,142(1-3):200-205. |
| APA | Li M.,Wang Y.,Zheng XB.,Ikeda M.,Iwata N.,...&Su B[*].(2012).Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.SCHIZOPHRENIA RESEARCH,142(1-3),200-205. |
| MLA | Li M,et al."Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility".SCHIZOPHRENIA RESEARCH 142.1-3(2012):200-205. |
入库方式： OAI收割
来源：昆明动物研究所
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