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Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau

文献类型：期刊论文

作者Qi XB1; Cui CY2; Peng Y1,3; Zhang XM1,3; Yang ZH1,3; Zhong H1; Xiang K1,3; Cao XY1,3; Wang Y1,3; Ouzhuluobu2
刊名MOLECULAR BIOLOGY AND EVOLUTION
出版日期2013
卷号30期号:8页码:1761-1778
关键词Tibetan Plateau demographic history human migration last glacial maximum
通讯作者shihong@mail.kiz.ac.cn ; sub@mail.kiz.ac.cn
合作状况其它
英文摘要Tibetans live on the highest plateau in the world, their current population size is approximately 5 million, and most of them live at an altitude exceeding 3,500 m. Therefore, the Tibetan Plateau is a remarkable area for cultural and biological studies of human population history. However, the chronological profile of the Tibetan Plateau's colonization remains an unsolved question of human prehistory. To reconstruct the prehistoric colonization and demographic history of modern humans on the Tibetan Plateau, we systematically sampled 6,109 Tibetan individuals from 41 geographic populations across the entire region of the Tibetan Plateau and analyzed the phylogeographic patterns of both paternal (n = 2,354) and maternal (n = 6,109) lineages as well as genome-wide single nucleotide polymorphism markers (n = 50) in Tibetan populations. We found that there have been two distinct, major prehistoric migrations of modern humans into the Tibetan Plateau. The first migration was marked by ancient Tibetan genetic signatures dated to approximately 30,000 years ago, indicating that the initial peopling of the Tibetan Plateau by modern humans occurred during the Upper Paleolithic rather than Neolithic. We also found evidences for relatively young (only 7-10 thousand years old) shared Y chromosome and mitochondrial DNA haplotypes between Tibetans and Han Chinese, suggesting a second wave of migration during the early Neolithic. Collectively, the genetic data indicate that Tibetans have been adapted to a high altitude environment since initial colonization of the Tibetan Plateau in the early Upper Paleolithic, before the last glacial maximum, followed by a rapid population expansion that coincided with the establishment of farming and yak pastoralism on the Plateau in the early Neolithic.
收录类别SCI
资助信息This work was supported by the National 973 Program of China grants 2012CB518202 to T.W. and X.Q., 2011CB512107 to Ou.; the National Natural Science Foundation of China grants 91231203 and 31123005 to B.S., 30870295 to X.Q., and 91131001 to H.S.; State Key Laboratory of Genetic Resources and Evolution grants GREKF11-02 to Ou., GREKF10-02 to C.C., and GREKF13-04 to T.W.; the Ministry of Education of China grant 707051 to Ou.; and the Natural Science Foundation of Yunnan Province grant 2009CD107 and 2010CI044 to H.S.
语种英语
WOS记录号WOS:000321820400003
公开日期2013-08-30
源URL[http://159.226.149.42:8088/handle/152453/7619]  
专题昆明动物研究所_比较基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
2.High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa, China
3.University of Chinese Academy of Sciences, Beijing, China
4.People’s Hospital of Dangxiong County, Dangxiong, China
5.National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining, China
6.Department of Epidemiology and Biostatistics, Harvard School of Public Health
推荐引用方式
GB/T 7714		 Qi XB,Cui CY,Peng Y,et al. Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau[J]. MOLECULAR BIOLOGY AND EVOLUTION,2013,30(8):1761-1778.
APA Qi XB.,Cui CY.,Peng Y.,Zhang XM.,Yang ZH.,...&Su B[*].(2013).Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau.MOLECULAR BIOLOGY AND EVOLUTION,30(8),1761-1778.
MLA Qi XB,et al."Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau".MOLECULAR BIOLOGY AND EVOLUTION 30.8(2013):1761-1778.

入库方式： OAI收割

来源：昆明动物研究所

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