Evolutionary survey of druggable protein targets with respect to their subcellular localizations
文献类型：期刊论文
| 作者 | Wang XT1; Wang R2; Zhang YF[*]3; Zhang H[*]4 |
| 刊名 | GENOME BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:7页码:1291-2197 |
| 关键词 | drug targets subcellular localization Ka/Ks druggable genome pharmacophylogenomics |
| 通讯作者 | youngorchuang@hotmail.com ; zhanghao827@163.com |
| 合作状况 | 其它 |
| 英文摘要 | The druggable subset of the human genome, termed the "druggable genome," provides the pharmaceutical industry with a unique opportunity for the advancement of new therapeutic interventions for a multitude of diseases and disorders. To date, there is no systematic assessment of the evolutionary history and nature of the defined druggable proteins derived from the contemporary druggable genome (i.e., proteins that bind or are predicted to bind with high affinity to a biologic). An understanding of drug-protein target interactions in specific cellular compartments is crucial for the optimal therapeutic delivery of pharmaceutical agents, as well as for preclinical drug trials in model animals. This study applied the concept of pharmacophylogenomics, the study of genes, evolution, and drug targets, to conduct an evolutionary survey of drug targets with respect to their subcellular localizations. Using multiple models and modes of druggable genome comparison, the results concordantly indicated that orthologous drug targets with a nuclear localization in the human, macaque, mouse, and rat showed a higher trend for evolutionary conservation compared with drug targets in the cell membrane and the extracellular compartment. As such, this study provides important information regarding druggable protein targets and the druggable genome at the pharmacophylogenomics level. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Natural Science Foundation of China (grant no. 31272401 and U1036604). |
| 语种 | 英语 |
| WOS记录号 | WOS:000324594500004 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7674]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.School of Agriculture, Ludong University, Yantai, China 2.The Graduate School of Kunming Medical University, Institute of Clinical and Basic Medical Sciences, The First People’s Hospital Yunnan Province, Kunming Medical University, Kunming, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.College of Animal Science and Technology, China Agricultural University, Beijing, China |
| 推荐引用方式 GB/T 7714 | Wang XT,Wang R,Zhang YF[*],et al. Evolutionary survey of druggable protein targets with respect to their subcellular localizations[J]. GENOME BIOLOGY AND EVOLUTION,2013,5(7):1291-2197. |
| APA | Wang XT,Wang R,Zhang YF[*],&Zhang H[*].(2013).Evolutionary survey of druggable protein targets with respect to their subcellular localizations.GENOME BIOLOGY AND EVOLUTION,5(7),1291-2197. |
| MLA | Wang XT,et al."Evolutionary survey of druggable protein targets with respect to their subcellular localizations".GENOME BIOLOGY AND EVOLUTION 5.7(2013):1291-2197. |
入库方式： OAI收割
来源：昆明动物研究所
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