A genetic adaptive pattern-low hemoglobin concentration in the himalayan highlanders
文献类型：期刊论文
| 作者 | Wu TY[*]1,2; Liu FY1; Ouzhou-Loubu2; Cui CY2; Qi XB3; Su B3 |
| 刊名 | 中国应用生理学杂志
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:6页码:481-493 |
| 关键词 | hemoglobin concentration evolution erythropoiesis high altitude adaptation Himalayan populations genetic variation chronic mountain sickness |
| 通讯作者 | wutianyiqh@hotmail.com |
| 英文摘要 | Mean hemoglobin (Hb) concentration of about 3 500 subjects derived from 17 studies of Himalayan highlanders (Tibetans, Sherpas, and Ladakhis) was compared with lowlanders (Chinese Han, Indian Tamils) lived in the Himalayas, and European climbers during Everest expeditions as well as Andean natives. The results found that Hb concentration in Himalayan highlanders was systemically lower than those reported for Andean natives and lowland immigrants. These comparative data demonstrated that a healthy native population may successfully reside at high altitude without a significant elevation in Hb, and the lower Hb levels of Himalayan highlanders than those of migrated lowlanders and Andean natives are an example of favourable adaptation over the generations. In addition, excessive polycythemia has frequently been used as a marker of chronic mountain sickness (CMS). Altitude populations who have a higher Hb concentration also have a higher incidence of CMS. The low Hb in Himalayans suggested as showing adaptation over many generations in Tibetan stock. Recent work in Tibet, suggested that Tibetans there may have adapted to high altitude as a result of evolutionary pressure selecting for genes which give an advantage at altitude. All of the population genomic and statistical analysis indicated that EPAS1 and EGLN1 are mostly likely responsible for high altitude adaptation and closely related to low Hb concentration in Tibetans. These data supported the hypothesis that Himalayan highlanders have evolved a genetically different erythropoietic response to chronic hypoxia by virtue of their much longer exposure to high altitude. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the “973” National Basic Research Program (2012 CB 518202, and “Pre-973” National Basic Research Program (2012 CB 722506), PRC. |
| 语种 | 英语 |
| 公开日期 | 2014-06-03 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7862]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Qinghai 810012 2.High Altitude Medical Research Center, University of Tibet, Lhasa 850000 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Academy of Science, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Wu TY[*],Liu FY,Ouzhou-Loubu,et al. A genetic adaptive pattern-low hemoglobin concentration in the himalayan highlanders[J]. 中国应用生理学杂志,2013,29(6):481-493. |
| APA | Wu TY[*],Liu FY,Ouzhou-Loubu,Cui CY,Qi XB,&Su B.(2013).A genetic adaptive pattern-low hemoglobin concentration in the himalayan highlanders.中国应用生理学杂志,29(6),481-493. |
| MLA | Wu TY[*],et al."A genetic adaptive pattern-low hemoglobin concentration in the himalayan highlanders".中国应用生理学杂志 29.6(2013):481-493. |
入库方式： OAI收割
来源：昆明动物研究所
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