Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia
文献类型：期刊论文
| 作者 | Zhang R1,2; Zhang H4; Li M3; Li HB1; Li Y1; Valenzuela RK5,6; Su B3; Ma J[*]1 |
| 刊名 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
 |
| 出版日期 | 2013 |
| 卷号 | 46期号:X页码:64-69 |
| 关键词 | Association CMYA5 Haplotype Schizophrenia SNP |
| 通讯作者 | majie.paper@gmail.com |
| 英文摘要 | Recently, CMYA5 was suggested as a susceptibility gene for schizophrenia based on two independent studies utilizing different ethnic samples. We designed a case-control study to examine whether 21 SNPs contained within CMYA5 were associated with the disorder in a western Han Chinese sample comprised of 488 schizophrenia patients and 516 healthy control subjects. The allele distribution of SNPs rs7714250, rs16877135 and rs13158477 showed significant association with schizophrenia (P-uncorrected = 0.008, P-uncorrected = 0.04, and P-uncorrected = 0.009, respectively) as well as the genotype distribution in the Cochran-Armitage trend test (P-uncorrected = 0.008, P-uncorrected = 0.037 and P-uncorrected = 0.011, respectively). After Bonferroni correction, rs7714250 showed a trend of association with schizophrenia both in allele distribution (P-corrected = 0.088) and genotype distribution (P-corrected = 0.088). Furthermore, significant associations were found in several two-, three-, four-, and five-SNP tests of haplotype analyses. Replications of the association of CMYA5 with schizophrenia across various studies suggest that it is very likely a potential common schizophrenia-related gene worldwide. Functional studies correlating CMYA5 with DTNBP1 and PKA warrant further investigation of the molecular basis of this gene in relationship to the signal transduction pathway(s) underlying the pathogenesis of schizophrenia. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by funding from the Fundamental Research Funds for the Central Universities (No. 2012JDGZ07, No. XJJ2012124); the Key Project of International Scientific Cooperation of Shaanxi Province (No. 2013KW25-02) and the National Natural Science Foundation of China (No. U1202225). |
| 语种 | 英语 |
| WOS记录号 | WOS:000324480900010 |
| 公开日期 | 2014-10-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8081]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_转化基因组 |
| 作者单位 | 1.Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, China 2.Xi'an Hong Hui Hospital, the Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Psychiatry Department, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China 5.Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 6.Life Sciences Institute, National University of Singapore, Singapore |
| 推荐引用方式 GB/T 7714 | Zhang R,Zhang H,Li M,et al. Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,46(X):64-69. |
| APA | Zhang R.,Zhang H.,Li M.,Li HB.,Li Y.,...&Ma J[*].(2013).Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,46(X),64-69. |
| MLA | Zhang R,et al."Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 46.X(2013):64-69. |
入库方式： OAI收割
来源：昆明动物研究所
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