Evolutionary Origin and Human-Specific Expansion of a Cancer/Testis Antigen Gene Family
文献类型：期刊论文
| 作者 | Zhang Q[*]1; Su B[*]2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2014 |
| 卷号 | 31期号:9页码:2365-2375 |
| 关键词 | CTAGE gene family cancer/testis antigen positive selection gene duplication retroposition human-specific expansion |
| 通讯作者 | quzhang@post.harvard.edu ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Cancer/testis (CT) antigens are encoded by germline genes and are aberrantly expressed in a number of human cancers. Interestingly, CT antigens are frequently involved in gene families that are highly expressed in germ cells. Here, we presented an evolutionary analysis of the CTAGE (cutaneous T-cell-lymphoma-associated antigen) gene family to delineate its molecular history and functional significance during primate evolution. Comparisons among human, chimpanzee, gorilla, orangutan, macaque, marmoset, and other mammals show a rapid and primate specific expansion of CTAGE family, which starts with an ancestral retroposition in the haplorhini ancestor. Subsequent DNA-based duplications lead to the prosperity of single-exon CTAGE copies in catarrhines, especially in humans. Positive selection was identified on the single-exon copies in comparison with functional constraint on the multiexon copies. Further sequence analysis suggests that the newly derived CTAGE genes may obtain regulatory elements from long terminal repeats. Our result indicates the dynamic evolution of primate genomes, and the recent expansion of this CT antigen family in humans may confer advantageous phenotypic traits during early human evolution. |
| 收录类别 | SCI |
| 资助信息 | The authors appreciate helpful comments from anonymous reviewers. This work was supported by the Department of Human Evolutionary Biology, Harvard University, by grants fromtheNational973projectofChina(2011CBA00401),and theNationalNaturalScienceFoundationofChina(31130051, 31301028, and 31321002). |
| 语种 | 英语 |
| WOS记录号 | WOS:000343401100010 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8176]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Human Evolutionary Biology, Graduate School of Art and Science, Harvard University 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Zhang Q[*],Su B[*]. Evolutionary Origin and Human-Specific Expansion of a Cancer/Testis Antigen Gene Family[J]. MOLECULAR BIOLOGY AND EVOLUTION,2014,31(9):2365-2375. |
| APA | Zhang Q[*],&Su B[*].(2014).Evolutionary Origin and Human-Specific Expansion of a Cancer/Testis Antigen Gene Family.MOLECULAR BIOLOGY AND EVOLUTION,31(9),2365-2375. |
| MLA | Zhang Q[*],et al."Evolutionary Origin and Human-Specific Expansion of a Cancer/Testis Antigen Gene Family".MOLECULAR BIOLOGY AND EVOLUTION 31.9(2014):2365-2375. |
入库方式： OAI收割
来源：昆明动物研究所
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