Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans
文献类型：期刊论文
| 作者 | Li M[*]1; Wu DD2; Su B2; Chasman DI6,7; Chu AY6; Huang T8; Qi L8,9; Zheng Y8; Yao YG1,3; Luo XJ1 |
| 刊名 | SCHIZOPHRENIA BULLETIN
 |
| 出版日期 | 2016 |
| 卷号 | 42期号:1页码:178-190 |
| 关键词 | SLC39A8 nonsynonymous SNP Europe pleiotropic effects positive selection schizophrenia |
| 通讯作者 | limingkiz@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Natural selection has played important roles in optimizing complex human adaptations. However, schizophrenia poses an evolutionary paradox during human evolution, as the illness has strongly negative effects on fitness, but persists with a prevalence of ~0.5% across global populations. Recent studies have identified numerous risk variations in diverse populations, which might be able to explain the stable and high rate of schizophrenia morbidity in different cultures and regions, but the questions about why the risk alleles derived and maintained in human gene pool still remain unsolved. Here, we studied the evolutionary pattern of a schizophrenia risk variant rs13107325 (P -8 in Europeans) in the SLC39A8 gene. We found the SNP is monomorphic in Asians and Africans with risk (derived) T-allele totally absent, and further evolutionary analyses showed the T-allele has experienced recent positive selection in Europeans. Subsequent exploratory analyses implicated that the colder environment in Europe was the likely selective pressures, ie, when modern humans migrated "out of Africa" and moved to Europe mainland (a colder and cooler continent than Africa), new alleles derived due to positive selection and protected humans from risk of hypertension and also helped them adapt to the cold environment. The hypothesis was supported by our pleiotropic analyses with hypertension and energy intake as well as obesity in Europeans. Our data thus provides an intriguing example to illustrate a possible mechanism for maintaining schizophrenia risk alleles in the human gene pool, and further supported that schizophrenia is likely a product caused by pleiotropic effect during human evolution. |
| 学科主题 | pleiotropic effects ; positive selection ; schizophrenia |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9336]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_神经系统疾病 昆明动物研究所_转化基因组 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 3.CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai, China 4.College of Life Science, Anhui University, Hefei, Anhui, China 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China 6.Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, US 7.Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, US 8.The Department of Nutrition, Harvard School of Public Health, Boston, MA, US 9.The Channing Laboratory and the Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA |
| 推荐引用方式 GB/T 7714 | Li M[*],Wu DD,Su B,et al. Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans[J]. SCHIZOPHRENIA BULLETIN,2016,42(1):178-190. |
| APA | Li M[*].,Wu DD.,Su B.,Chasman DI.,Chu AY.,...&Liu JW.(2016).Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans.SCHIZOPHRENIA BULLETIN,42(1),178-190. |
| MLA | Li M[*],et al."Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans".SCHIZOPHRENIA BULLETIN 42.1(2016):178-190. |
入库方式： OAI收割
来源：昆明动物研究所
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