Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations
文献类型：期刊论文
| 作者 | Li M1,2; Ohi K2,3; Chen CS4; He QH4; Liu JW1; Chen CS5; Luo XJ6; Dong Q[*]4; Hashimoto R[*]3,7; Su B[*]1 |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:12页码:2883.e1-2 |
| 关键词 | Hippocampal volume GWAS Replication study Asian |
| 通讯作者 | dongqi@bnu.edu.cn ; hashimor@psy.med.osaka-u.ac.jp ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Hippocampal volume is a key brain structure for learning ability and memory process, and hippocampal atrophy is a recognized biological marker of Alzheimer's disease. However, the genetic bases of hippocampal volume are still unclear although it is a heritable trait. Genome-wide association studies (GWASs) on hippocampal volume have implicated several significantly associated genetic variants in Europeans. Here, to test the contributions of these GWASs identified genetic variants to hippocampal volume in different ethnic populations, we screened the GWAS-identified candidate single-nucleotide polymorphisms in 3 independent healthy Asian brain imaging samples (a total of 990 subjects). The results showed that none of these single-nucleotide polymorphisms were associated with hippocampal volume in either individual or combined Asian samples. The replication results suggested a complexity of genetic architecture for hippocampal volume and potential genetic heterogeneity between different ethnic populations. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National 973 project of China (2011CBA00401), the National Natural Science Foundation of China (U1202225), and the 111 Project (B07008) of the Ministry of Education of China, the Japanese Ministry of Edu- cation, Culture, Sports, Science and Technology (18689030, 22390225). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9398]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_神经系统疾病 昆明动物研究所_转化基因组 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, USA 3.Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan 4.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China 5.Department of Psychology and Social Behavior, University of California, Irvine, CA, USA 6.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 7.Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan |
| 推荐引用方式 GB/T 7714 | Li M,Ohi K,Chen CS,et al. Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations[J]. NEUROBIOLOGY OF AGING,2014,35(12):2883.e1-2. |
| APA | Li M.,Ohi K.,Chen CS.,He QH.,Liu JW.,...&Su B[*].(2014).Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations.NEUROBIOLOGY OF AGING,35(12),2883.e1-2. |
| MLA | Li M,et al."Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations".NEUROBIOLOGY OF AGING 35.12(2014):2883.e1-2. |
入库方式： OAI收割
来源：昆明动物研究所
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