No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects
文献类型：期刊论文
| 作者 | Li M1; Huang L2; Wang J3; Su B[*]3; Luo XJ[*]1 |
| 刊名 | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
 |
| 出版日期 | 2016 |
| 卷号 | 171期号:2页码:160-168 |
| 关键词 | brain volume genetic association healthy individuals schizophrenia |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Previous studies have suggested that genetic variants for schizophrenia susceptibility might contribute to structural brain volume variations inschizophrenia patients, including total brain volume, hippocampal volume, and amygdalar volume. However, whether these schizophreniasusceptibility variants are associated with macroscopic structural brain volume (i.e., intracranial volume, total brain volume, and hippocampal volume) in healthy subjects is still unclear. In this study, we investigated the associations between 47 schizophrenia susceptibility variants (from 25 well-characterized schizophrenia susceptibility genes) and cranial volume variation in a healthy Chinese sample (N = 1,013). We also extracted theassociation between these 47 schizophrenia risk variants and the macroscopic structural brain volume (intracranial volume, total brain volume and hippocampal volume) in a large healthy sample of European ancestry (ENIGMA sample, N = 5,775). We identified several single-nucleotide polymorphisms (SNPs) nominally associated with intracranial volume, total brain volume, and hippocampal volume at P < 0.05 (uncorrected). However, after Bonferroni corrections for multiple testing, no SNP showed significant association. Hence, our results do not support previous observations thatschizophrenia susceptibility variants are associated with brain structure (e.g., hippocampal volume) in healthy individuals, and indicate that singleschizophrenia risk variant may not contribute significantly to macroscopic brain structure (e.g., intracranial volume or hippocampal volume) variation inhealthy subjects. |
| 收录类别 | SCI |
| 资助信息 | X.J.Lwassupportedbythe100TalentsProgram(BaiRenJiHua)of the Chinese Academy of Sciences, and the Thousand Talents Program (Recruitment Program of Global Youth Experts) of China.WethankHuiZhang,WeiZhang,YanjiaoLi,andXiaodong Shifor their technical support. We thank Nic Novak, Arthur Toga, Jason Stein, and Paul Thompson of USC for creating the Enigma- Vis website used for part of this paper. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9430]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_神经系统疾病 昆明动物研究所_转化基因组 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li M,Huang L,Wang J,et al. No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects[J]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,2016,171(2):160-168. |
| APA | Li M,Huang L,Wang J,Su B[*],&Luo XJ[*].(2016).No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects.American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,171(2),160-168. |
| MLA | Li M,et al."No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects".American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171.2(2016):160-168. |
入库方式： OAI收割
来源：昆明动物研究所
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