Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region
文献类型：期刊论文
| 作者 | Bhandari S1,4; Zhang XM1; Cui CY2; Bianba2; Liao SY1; Peng Y1; Zhang H1; Xiang K1; Shi H1,5; Ouzhuluobu2 |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e16429 |
| 通讯作者 | qixuebin@mail.kiz.ac.cn ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Sherpas living around the Himalayas are renowned as high-altitude mountain climbers but when and where the Sherpa people originated from remains contentious. In this study, we collected DNA samples from 582 Sherpas living in Nepal and Tibet Autonomous Region of China to study the genetic diversity of both their maternal (mitochondrial DNA) and paternal (Y chromosome) lineages. Analysis showed that Sherpas share most of their paternal and maternal lineages with indigenous Tibetans, representing a recently derived sub-lineage. The estimated ages of two Sherpa-specific mtDNA sub-haplogroups (C4a3b1 and A15c1) indicate a shallow genetic divergence between Sherpas and Tibetans less than 1,500 years ago. These findings reject the previous theory that Sherpa and Han Chinese served as dual ancestral populations of Tibetans, and conversely suggest that Tibetans are the ancestral populations of the Sherpas, whose adaptive traits for high altitude were recently inherited from their ancestors in Tibet. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National 973 Program of China (2012CB518202), the National Natural Science Foundation of China (31401064, 31130051, 91231203, 31371269, 31460287, 31360032 and 81460012), the State Key Laboratory of Genetic Resources and Evolution (GREKF13-04, GREKF12-04), and the Zhufeng Scholar Program of Tibetan University. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9479]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Chin 2.2 High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China 3.National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining 810012, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China 5.Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China |
| 推荐引用方式 GB/T 7714 | Bhandari S,Zhang XM,Cui CY,et al. Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region[J]. Scientific Reports,2015,5(X):e16429. |
| APA | Bhandari S.,Zhang XM.,Cui CY.,Bianba.,Liao SY.,...&Su B[*].(2015).Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region.Scientific Reports,5(X),e16429. |
| MLA | Bhandari S,et al."Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region".Scientific Reports 5.X(2015):e16429. |
入库方式： OAI收割
来源：昆明动物研究所
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