A genetic mechanism for convergent skin lightening during recent human evolution
文献类型：期刊论文
| 作者 | Yang ZH1,2,13; Zhong H3; Luo X1,2; Xu SH5; Chen H6; Lu DS5; Han YL7; Li JK8; Chen J4; Fu LJ8 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2016 |
| 卷号 | 33期号:5页码:1177-1187 |
| 关键词 | OCA2 East Asians skin lightening pigmentation genes |
| 通讯作者 | sub@mail.kiz.ac.cn ; mengam@mail.tsinghua.edu.cn ; shihong@kbimed.com. |
| 合作状况 | 其它 |
| 英文摘要 | Skin lightening among Eurasians is thought to have been a convergence occurring independently in Europe and East Asia as an adaptation to high latitude environments. Among Europeans, several genes responsible for such lightening have been found, but the information available for East Asians is much more limited. Here, a genome-wide comparison between dark-skinned Africans and Austro-Asiatic speaking aborigines and light-skinned northern Han Chinese identified the pigmentation gene OCA2, showing unusually deep allelic divergence between these groups. An amino acid substitution (His615Arg) of OCA2 prevalent in most East Asian populations-but absent in Africans and Europeans-was significantly associated with skin lightening among northern Han Chinese. Further transgenic and targeted gene modification analyses of zebrafish and mouse both exhibited the phenotypic effect of the OCA2 variant manifesting decreased melanin production. These results indicate that OCA2 plays an important role in the convergent skin lightening of East Asians during recent human evolution. |
| 收录类别 | SCI |
| 资助信息 | ThisstudywassupportedbygrantsfromtheStrategicPriority Research Program of the Chinese Academy of Sciences (XDB13010000); the National Natural Science Foundation of China (91131001, 91231203, 31321002, 31123005, 31371268, and 31371269); the Natural Science Foundation of Yunnan Province (2010CI044); State Key Laboratory of Genetic Resources and Evolution grant (GREKF15-06); and the Personnel Training Project of Yunnan Province (KKSY201526061). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9522]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China 3.Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA 4.Capacity Development Facilitator for Handicap International Federation and Freelance researcher, Battambang, Kingdom of Cambodia 5.Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China 6.State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China 7.Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 8.Center for Computational Genomics, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China 9.College of Life Science, Liaoning Normal University, Dalian 116029, China 10.No.1 School of Clinical Medicine of Kunming Medical University, Kunming 650223, China; |
| 推荐引用方式 GB/T 7714 | Yang ZH,Zhong H,Luo X,et al. A genetic mechanism for convergent skin lightening during recent human evolution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2016,33(5):1177-1187. |
| APA | Yang ZH.,Zhong H.,Luo X.,Xu SH.,Chen H.,...&Meng AM[*].(2016).A genetic mechanism for convergent skin lightening during recent human evolution.MOLECULAR BIOLOGY AND EVOLUTION,33(5),1177-1187. |
| MLA | Yang ZH,et al."A genetic mechanism for convergent skin lightening during recent human evolution".MOLECULAR BIOLOGY AND EVOLUTION 33.5(2016):1177-1187. |
入库方式： OAI收割
来源：昆明动物研究所
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