Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception
文献类型：期刊论文
| 作者 | Yang S1,2,3; Liu Y1,2,3; Su B[*]1,2; Lin AA4; Cavalli-Sforza LL4; Zhao ZM1,5,6 |
| 刊名 | GENE
 |
| 出版日期 | 2005 |
| 卷号 | 352期号:X页码:30-35 |
| 关键词 | GPCRs Human-specific substitution Darwinian positive selection Drug target |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | MRGX2, a G-protein-coupled receptor, is specifically expressed in the sensory neurons of the human peripheral nervous system and involved in nociception. Here, we studied DNA polymorphism patterns and evolution of the MRGX2 gene in world-wide human populations and the representative nonhuman primate species. Our results demonstrated that MRGX2 had undergone adaptive changes in the path of human evolution, which were likely caused by Darwinian positive selection. The patterns of DNA sequence polymorphisms in human populations showed an excess of derived substitutions, which against the expectation of neutral evolution, implying that the adaptive evolution of MRGX2 in humans was a relatively recent event. The reconstructed secondary structure of the human MRGX2 revealed that three of the four human-specific amino acid substitutions were located in the extra-cellular domains. Such critical substitutions may alter the interactions between MRGX2 protein and its ligand, thus, potentially led to adaptive changes of the pain-perception-related nervous system during human evolution. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the Chinese Academy of Sciences (KSCX2-SW-121), the National Natural Science Foundation of China (30370755) and the Natural Science Foundation of Yunnan Province of China. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9662]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Graduate School of Chinese Academy of Sciences, Beijing, China 4.Department of Genetics, Stanford University, Stanford, CA, United States 5.Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States 6.Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, United States |
| 推荐引用方式 GB/T 7714 | Yang S,Liu Y,Su B[*],et al. Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception[J]. GENE,2005,352(X):30-35. |
| APA | Yang S,Liu Y,Su B[*],Lin AA,Cavalli-Sforza LL,&Zhao ZM.(2005).Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.GENE,352(X),30-35. |
| MLA | Yang S,et al."Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception".GENE 352.X(2005):30-35. |
入库方式： OAI收割
来源：昆明动物研究所
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