Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory
文献类型：期刊论文
| 作者 | Li Y1,3,4; Qian YP2; Sun W5; Ma RM6; Su B[*]1,2; Yu XJ1; Wang YQ1; Dong DG5 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2004 |
| 卷号 | 21期号:11页码:2111-2115 |
| 关键词 | neuropsin alternative splicing cognition molecular evolution |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Neuropsin is a secreted-type serine protease involved in learning and memory. The type II splice form of neuropsin is abundantly expressed in the human brain but not in the mouse brain. We sequenced the type II-spliced region of neuropsin gene in humans and representative nonhuman primate species. Our comparative sequence analysis showed that only the hominoid species (humans and apes) have the intact open reading frame of the type II splice form, indicating that the type II neuropsin originated recently in the primate lineage about 18 MYA. Expression analysis using RT-PCR detected abundant expression of the type II form in the frontal lobe of the adult human brain, but no expression was detected in the brains of lesser apes and Old World monkeys, indicating that the type II form of neuropsin only became functional in recent time, and it might contribute to the progressive change of cognitive abilities during primate evolution. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Chinese Academy of Sciences (KSCX2- SW-121), the National Science Foundation of China (NSFC), and the Natural Science Foundation of Yunnan Province, China. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9668]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan, China 2.Center for Genome Information, Department of Environmental Health, University of Cincinnati 3.Department of Chemistry, Qujing Teachers University, Qujing, Yunnan, China 4.Graduate School of the Chinese Academy of Sciences, Beijing, China 5.The First People’s Hospital of Qujing, Qujing, Yunnan, China 6.The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li Y,Qian YP,Sun W,et al. Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory[J]. MOLECULAR BIOLOGY AND EVOLUTION,2004,21(11):2111-2115. |
| APA | Li Y.,Qian YP.,Sun W.,Ma RM.,Su B[*].,...&Dong DG.(2004).Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory.MOLECULAR BIOLOGY AND EVOLUTION,21(11),2111-2115. |
| MLA | Li Y,et al."Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory".MOLECULAR BIOLOGY AND EVOLUTION 21.11(2004):2111-2115. |
入库方式： OAI收割
来源：昆明动物研究所
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