Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages
文献类型：期刊论文
| 作者 | Shi L1,2,3,4; Zhang ZG1,2,3; Su B[*]1,2,3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e21181 |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 英文摘要 | There are many differences in brain structure and function between males and females. However, how these differences were manifested during development and maintained through adulthood are still unclear. Here we present a time series analyses of genome-wide transcription profiles of the human brain, and we identified genes showing sex biased expression at major developmental stages (prenatal time, early childhood, puberty time and adulthood). We observed a great number of genes (>2,000 genes) showing between-sex expression divergence at all developmental stages with the greatest number (4,164 genes) at puberty time. However, there are little overlap of sex-biased genes among the major developmental stages, an indication of dynamic expression regulation of the sex-biased genes in the brain during development. Notably, the male biased genes are highly enriched for genes involved in neurological and psychiatric disorders like schizophrenia, bipolar disorder, Alzheimer's disease and autism, while no such pattern was seen for the female-biased genes, suggesting that the differences in brain disorder susceptibility between males and females are likely rooted from the sex-biased gene expression regulation during brain development. Collectively, these analyses reveal an important role of sex biased genes in brain development and neurodevelopmental disorders. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (31130051, 31301028 and 31321002) and the Natural Science Foundation of Yunnan Province (2007C100M and 2009CD107). This study was also supported by funding from West light Doctoral program and Youth Innovation Promotion Association of CAS. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10318]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650000, China 4.The Molecular & Behavioral Neuroscience Institute (MBNI), University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA |
| 推荐引用方式 GB/T 7714 | Shi L,Zhang ZG,Su B[*]. Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages[J]. SCIENTIFIC REPORTS,2016,6(X):e21181. |
| APA | Shi L,Zhang ZG,&Su B[*].(2016).Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages.SCIENTIFIC REPORTS,6(X),e21181. |
| MLA | Shi L,et al."Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages".SCIENTIFIC REPORTS 6.X(2016):e21181. |
入库方式： OAI收割
来源：昆明动物研究所
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