Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging
文献类型：期刊论文
| 作者 | Lam SM1; Chua GH1; Li XJ1; Su B2; Shui GH[*]1 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2016 |
| 卷号 | 7期号:35页码:55970-55989 |
| 关键词 | Gerotarget Rhesus macaques aging docosahexaenoic acids lipidomics polyunsaturated fatty acids |
| 通讯作者 | ghshui@genetics.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Lipidomic analyses of the frontal cortex of Rhesus macaques across three selected age groups (young, sexually-mature, old) revealed that docosahexaenoic acids (DHAs) displayed notable and unique accretions in sexually-mature macaques for all phospholipid classes examined, which were not observable in all remaining polyunsaturated fatty acids (PUFAs) investigated. On the other hand, arachidonic acid (ARA) exhibited sharp attritions in the membrane lipidomes of sexually-mature macaques, a decline which was attenuated only for cardiolipins (CLs). DHA enrichment in phospholipids was lost in old macaques, with accompanying augmentations in very-long-chain sphingomyelins (VLC-SMs). Age-dependent alterations in membrane lipidomes point to a possibly complex temporal interplay between DHA-enriched membrane microdomains and SM-/cholesterol-rich rafts in neural membranes during normative aging. Lipid co-regulation data revealed an increasingly intense degree of co-regulation between membrane lipid classes with age, and suggest that reduction in CLs during normative brain aging may prompt alternative membrane lipid synthetic pathways driven by a compromised energy availability in the aging brain. |
| 收录类别 | SCI |
| 资助信息 | This work was financially supported by grants from “100 Talents Program of Chinese Academy of Sciences” and the National Natural Science Foundation of China (31371515, 31130051, 3150040263), the National Basic Research Program of China (973 Program; 2012CB825504) and the Chinese Academy of Sciences (XDA04020413-02, XDB13010000). This work was also financially supported by the Special Financial Grant awarded to S.M. Lam from the China Postdoctoral Science Foundation (Grant No: 2014T70137). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10394]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Lam SM,Chua GH,Li XJ,et al. Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging[J]. ONCOTARGET,2016,7(35):55970-55989. |
| APA | Lam SM,Chua GH,Li XJ,Su B,&Shui GH[*].(2016).Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging.ONCOTARGET,7(35),55970-55989. |
| MLA | Lam SM,et al."Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging".ONCOTARGET 7.35(2016):55970-55989. |
入库方式： OAI收割
来源：昆明动物研究所
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