Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution
文献类型：期刊论文
| 作者 | Mendizabal I1,2; Shi L3,4; Keller TE1; Konopka G5; Preuss TM6; Hsieh TF7; Hu EZ3,8; Zhang Z3; Su B[*]3; Yi SV[*]1 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2016 |
| 卷号 | 33期号:11页码:2947-2959 |
| 关键词 | DNA methylation human brain evolution transcriptional divergence differentially methylated regions epigenomes |
| 通讯作者 | soojinyi@gatech.edu |
| 合作状况 | 其它 |
| 英文摘要 | How do epigenetic modifications change across species and how do these modifications affect evolution? These are fundamental questions at the forefront of our evolutionary epigenomic understanding. Our previous work investigated human and chimpanzee brain methylomes, but it was limited by the lack of outgroup data which is critical for comparative (epi) genomic studies. Here, we compared whole genome DNA methylation maps from brains of humans, chimpanzees and also rhesus macaques (outgroup) to elucidate DNA methylation changes during human brain evolution. Moreover, we validated that our approach is highly robust by further examining 38 human-specific DMRs using targeted deep genomic and bisulfite sequencing in an independent panel of 37 individuals from five primate species. Our unbiased genome-scan identified human brain differentially methylated regions (DMRs), irrespective of their associations with annotated genes. Remarkably, over half of the newly identified DMRs locate in intergenic regions or gene bodies. Nevertheless, their regulatory potential is on par with those of promoter DMRs. An intriguing observation is that DMRs are enriched in active chromatin loops, suggesting human-specific evolutionary remodeling at a higher-order chromatin structure. These findings indicate that there is substantial reprogramming of epigenomic landscapes during human brain evolution involving noncoding regions. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Science Foundation [SBE-131719 to SVY], the National Institutes of Health [1R01MH103517-01A1 to SVY, GK and TMP], the Strategic Priority Research Program of the Chinese Academy of Sciences [XDB13010000 to BS], the National Natural Science Foundation of China [NSFC 31130051 to BS and NSFC to LS], the Youth Innovation Promotion Association of the Chinese Academy of Sciences [to LS], the Research Personnel Improvement Program by the Department of Education, Language Policy and Culture by the Basque Government [POS_2013_1_130 to IM]; and the Yerkes National Primate Center Base Grant [ORIP/OD P51OD011132]. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10411]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.School of Biological Sciences, Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 2.Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.The Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 5.Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 6.Division of Neuropharmacology and Neurologic Diseases & Center for Translational Social Neuroscience, Department of Pathology and Laboratory Medicine, Yerkes National Primate Research Center, Emory University School of Medicine, Emory University, Atlanta, GA 7.Department of Plant and Microbial Biology and Plants for Human Health Institute, North Carolina State University, Raleigh, NC 8.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Mendizabal I,Shi L,Keller TE,et al. Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2016,33(11):2947-2959. |
| APA | Mendizabal I.,Shi L.,Keller TE.,Konopka G.,Preuss TM.,...&Yi SV[*].(2016).Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution.MOLECULAR BIOLOGY AND EVOLUTION,33(11),2947-2959. |
| MLA | Mendizabal I,et al."Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution".MOLECULAR BIOLOGY AND EVOLUTION 33.11(2016):2947-2959. |
入库方式： OAI收割
来源：昆明动物研究所
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