Comparison of Pax1/9 locus reveals 500-Myr-old syntenic block and evolutionary conserved noncoding regions
文献类型：期刊论文
| 作者 | Wang W1; Zhong J1; Su B2,3; Zhou Y4; Wang YQ[*]1 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2007 |
| 卷号 | 24期号:3页码:784-791 |
| 关键词 | amphioxus conserved synteny ncECR duplication evolution |
| 通讯作者 | wangyq@xmu.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Identification of conserved genomic regions within and between different genomes is crucial when studying genome evolution. Here, we described regions of strong synteny conservation between vertebrate deuterostomes (tetrapods and teleosts) and invertebrate deuterostomes (amphioxus and sea urchin). The shared gene contents across phylogenetically distant species demonstrate that the conservation of the regions stemmed from an ancestral segment instead of a series of independent convergent events. Comparison of the syntenic regions allows us to postulate the primitive gene organization in the last common ancestor of deuterostomes and the evolutionary events that occurred to the 3 distinct lineages of sea urchin, amphioxus, and vertebrates after their separation. In addition, alignment of the syntenic regions led to the identification of 8 noncoding evolutionarily conserved regions shared between amphioxus and vertebrates. To our knowledge, this is the first report of conserved noncoding sequences shared by vertebrates and nonvertebrates. These noncoding sequences have high possibility of being elements that regulate neighboring genes. They are likely to be a factor in the maintenance of conserved synteny over long phylogenetic distance in different deuterostome lineages. |
| 收录类别 | SCI |
| 资助信息 | This work is supported by National Nature Science Foundation of China (No.30470938& No.30570208),NaturalScienceFoundationofFujianProv- ince,China(No.D0510002),andgrantfromtheScienceand Technology Bureau of Xiamen (No. 3502Z20042015). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10539]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Xiamen Univ, Key Lab Minist Educ Cell Biol & Tumor Cell Engn, Sch Life Sci, Xiamen, Peoples R China 2.Chinese Acad Sci, Key Lab Cell & Mol Evolut, Kunming Inst Zool, Kunming, Peoples R China 3.Chinese Acad Sci, Kunming Primate Res Ctr, Kunming, Peoples R China 4.Chinese Human Genome Ctr Shanghai, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang W,Zhong J,Su B,et al. Comparison of Pax1/9 locus reveals 500-Myr-old syntenic block and evolutionary conserved noncoding regions[J]. MOLECULAR BIOLOGY AND EVOLUTION,2007,24(3):784-791. |
| APA | Wang W,Zhong J,Su B,Zhou Y,&Wang YQ[*].(2007).Comparison of Pax1/9 locus reveals 500-Myr-old syntenic block and evolutionary conserved noncoding regions.MOLECULAR BIOLOGY AND EVOLUTION,24(3),784-791. |
| MLA | Wang W,et al."Comparison of Pax1/9 locus reveals 500-Myr-old syntenic block and evolutionary conserved noncoding regions".MOLECULAR BIOLOGY AND EVOLUTION 24.3(2007):784-791. |
入库方式： OAI收割
来源：昆明动物研究所
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