Detecting positive darwinian selection in brain-expressed genes during human evolution
文献类型：期刊论文
| 作者 | Qi XB1,2; Yang S1,2,5; Liu Y1,2,5; Chen XH1,2; Shi H1,2,5; Yu XJ1,2,5; Lin AA4; Cavalli-Sforza LL4; Zheng HK3,7; Wang J[*]3,6,7 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2007 |
| 卷号 | 52期号:3页码:324-335 |
| 关键词 | positive selection adaptive evolution brain-expressed gene hominoids |
| 通讯作者 | wangj@genomics.org.cn ; sub@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | To understand the genetic basis that underlies the phenotypic divergence between human and non-human primates, we screened a total of 7176 protein-coding genes expressed in the human brain and compared them with the chimpanzee orthologs to identity genes that show evidence of rapid evolution in the human lineage. Our results showed that the nonsynonymous/synonymous substitution (K-a/K-s,) ratio for genes expressed in the brain of human and chimpanzee is 0.3854, suggesting that the brain-expressed genes are under functional constraint. The X-linked human brain-expressed genes evolved more rapidly than autosomal ones. We further dissected the molecular evolutionary patterns of 34 candidate genes by sequencing representative primate species to identify lineage-specific adaptive evolution. Fifteen out of the 34 candidate genes showed evidence of positive Darwinian selection in human and/or chimpanzee lineages. These genes are predicted to play diverse functional roles in embryonic development, spermatogenesis and male fertility, signal transduction, sensory nociception, and neural function. This study together with others demonstrated the usefulness and power of phylogenetic comparison of multiple closely related species in detecting lineage-specific adaptive evolution, and the identification of the positively selected brain-expressed genes may add new knowledge to the understanding of molecular mechanism of human origin. |
| 收录类别 | SCI |
| 资助信息 | Supported by the Chinese Academy of Sciences (Grant Nos. KSCX2-SW-121 and GJHZ0518), the National Natural Science Foundation of China (Grant Nos. 30370755, 30440018, 30525028, 90208019, 90403130 and 30221004), the National 973 Project of China (Grant No. 2006CB701506), the Post-doctoral Fellowship of China (Grant No. 2005038271), Ministry of Science and Technology under program (Grant No. CNGI-04-15-7A), the Natural Science Foundation of Yunnan Province of China, China National Grid, and Danish Platform for Integrative Biology and Ole Rømer grants from the Danish Natural Science Research Council |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10540]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming 650223, China 3.eijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China 4.Department of Genetics, Stanford University, Stanford, USA 5.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 6.The Institute of Human Genetics, University of Aarhus, Aarhus C, DK-8000, Denmark 7.Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, DK-5230, Denmark |
| 推荐引用方式 GB/T 7714 | Qi XB,Yang S,Liu Y,et al. Detecting positive darwinian selection in brain-expressed genes during human evolution[J]. CHINESE SCIENCE BULLETIN,2007,52(3):324-335. |
| APA | Qi XB.,Yang S.,Liu Y.,Chen XH.,Shi H.,...&Liao CH.(2007).Detecting positive darwinian selection in brain-expressed genes during human evolution.CHINESE SCIENCE BULLETIN,52(3),324-335. |
| MLA | Qi XB,et al."Detecting positive darwinian selection in brain-expressed genes during human evolution".CHINESE SCIENCE BULLETIN 52.3(2007):324-335. |
入库方式： OAI收割
来源：昆明动物研究所
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