Ancestral Origins and Genetic History of Tibetan Highlanders
文献类型：期刊论文
| 作者 | Lu DS1,2; Lou HY1; Zhang C1,2; Lu Y1,2; Yang X1; Deng L1,2; Zhou Y1,2; Feng QD1,2; Yuan K1,2; Hu Y4 |
| 刊名 | AMERICAN JOURNAL OF HUMAN GENETICS
 |
| 出版日期 | 2016 |
| 卷号 | 99期号:3页码:580–594 |
| 通讯作者 | xushua@picb.ac.cn |
| 英文摘要 | The origin of Tibetans remains one of the most contentious puzzles in history, anthropology, and genetics. Analyses of deeply sequenced (30x-60x) genomes of 38 Tibetan highlanders and 39 Han Chinese lowlanders, together with available data on archaic and modem humans, allow us to comprehensively characterize the ancestral makeup of Tibetans and uncover their origins. Non-modem human sequences compose-6% of the Tibetan gene pool and form unique haplotypes in some genomic regions, where Denisovan-like, Neanderthal -like, ancient-Siberian-like, and unknown ancestries are entangled and elevated. The shared ancestry of Tibetan-enriched sequences dates back to similar to 62,000-38,000 years ago, predating the Last Glacial Maximum (LGM) and representing early colonization of the plateau. Nonetheless, most of the Tibetan gene pool is of modern human origin and diverged from that of Han Chinese similar to 15,000 to similar to 9,000 years ago, which can be largely attributed to post-LGM arrivals. Analysis of similar to 200 contemporary populations showed that Tibetans share ancestry with populations from East Asia (-82%), Central Asia and Siberia (similar to 11%), South Asia (similar to 6%), and western Eurasia and Oceania (similar to 1%). Our results support that Tibetans arose from a mixture of multiple ancestral gene pools but that their origins are much more complicated and ancient than previously suspected. We provide compelling evidence of the co-existence of Paleolithic and Neolithic ancestries in the Tibetan gene pool, indicating a genetic continuity between pre-historical highland-foragers and presentday Tibetans. In particular, highly differentiated sequences harbored in highlanders' genomes were most likely inherited from pre-LGM settlers of multiple ancestral origins (SUNDer) and maintained in high frequency by natural selection. |
| 收录类别 | SCI |
| 资助信息 | This work acknowledges financial support from the Strategic Prior- ity Research Program of the Chinese Academy of Sciences (CAS) (XDB13040100 to S.X.), the National Natural Science Foundation of China (91331204 to S.X., 31501011 to Y.L., 31601046 to H.L., 31260252 and 31460286 to L.K., and 31260263 to Y.G.), the Na- tional Science Fund for Distinguished Young Scholars (31525014 to S.X.), the Program of Shanghai Academic Research Leader (16XD1404700 to S.X.), the Science and Technology Commission of Shanghai Municipality (14YF1406800 to Y.L. and 16YF1413900 to H.L.), and the National High-Tech Research and Development Program (2012AA021802 to Y.Y.). S.X. is a Max Planck Indepen- dent ResearchGroup Leaderandamemberof theCASYouthInno- vation Promotion Association. S.X. also gratefully acknowledges support from the National Program for Top-Notch Young Innova- tive Talents of the ‘‘Wanren Jihua’’ Project. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10761]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computa- tional Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China 4.State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China 5.Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, China 6.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Chin 7.Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang Shaanxi 712082, China 8.Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China |
| 推荐引用方式 GB/T 7714 | Lu DS,Lou HY,Zhang C,et al. Ancestral Origins and Genetic History of Tibetan Highlanders[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2016,99(3):580–594. |
| APA | Lu DS.,Lou HY.,Zhang C.,Lu Y.,Yang X.,...&Wang YC.(2016).Ancestral Origins and Genetic History of Tibetan Highlanders.AMERICAN JOURNAL OF HUMAN GENETICS,99(3),580–594. |
| MLA | Lu DS,et al."Ancestral Origins and Genetic History of Tibetan Highlanders".AMERICAN JOURNAL OF HUMAN GENETICS 99.3(2016):580–594. |
入库方式： OAI收割
来源：昆明动物研究所
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