No accelerated evolution of 3 ' UTR region in human for brain-expressed genes
文献类型：期刊论文
| 作者 | Li Y1,2,3; Su B[*]1,2 |
| 刊名 | GENE
 |
| 出版日期 | 2006 |
| 卷号 | 383期号:X页码:38-42 |
| 关键词 | geneexpression rhesus monkey substitution rates neutral evolution |
| 通讯作者 | sub@mail.kiz.ac.cn |
| 英文摘要 | The difference in cognitive skills between humans and nonhuman primates is one of the major characters that define our own species. It was previously hypothesized that this divergence might be attributable to genetic differences at gene expression level, and the cis-regulating elements of gene 3'UTRs might play important roles in the post-transcriptional regulation of gene expression. In this study, we constructed a cDNA library from the prefrontal cortex of rhesus monkey and generated a total of 754 high-quality ESTs. Using rhesus macaque as outgroup, we calculated the evolutionary rates of the 3UTRs of 52 brain-expressed genes in humans and chimpanzees in order to dissect the role of natural selection during primate brain evolution. Comparison of 52 orthologous gene sequences of human and chimpanzee indicated that the mean substitution rates at nonsynonymous sites (K-a), synonymous sites (K-s) and 3'UTRs (K3(u)) are 0.0024, 0.0116 and 0.0117, respectively. Relative rate tests and acceleration index tests demonstrated that only a few genes had significant rate divergence between human and chimpanzee. The 3'UTRs of the brain-expressed genes in primates has a similar evolutionary rate with the synonymous sites of the gene coding region, indicating a neutral evolution of the 3'UTR sequences in human. |
| 资助信息 | This study was supported by grants from the Chinese Academy of Sciences (KSCX-SW-121), the National Natural Science Foundation of China (30370755, 30440018, 30525028), the Natural Science Foundation of Yunnan Province and the National 973 Project of China (2006CB701506). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10874]  |
| 专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Qujing Normal College, Qujing, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li Y,Su B[*]. No accelerated evolution of 3 ' UTR region in human for brain-expressed genes[J]. GENE,2006,383(X):38-42. |
| APA | Li Y,&Su B[*].(2006).No accelerated evolution of 3 ' UTR region in human for brain-expressed genes.GENE,383(X),38-42. |
| MLA | Li Y,et al."No accelerated evolution of 3 ' UTR region in human for brain-expressed genes".GENE 383.X(2006):38-42. |
入库方式： OAI收割
来源：昆明动物研究所
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