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Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season

文献类型：期刊论文

作者Yang S1,6; Shen Y2,3; Niu Y1; Hildebrandt TB4; JewgenoW K4; Goeritz F4; He X1; Zhou Q5; Ji W[*]1
刊名THERIOGENOLOGY
出版日期2008
卷号70期号:1页码:108-114
关键词rhesus monkey ovarian recovery repeated ovarian stimulation rhFSH ultrasonography
ISSN号0093-691X
通讯作者wji@mail.kiz.ac.cn
英文摘要We studied the effects of repeated stimulation by recombinant human FSH (rhFSH) at various time intervals during a physiologic breeding season in rhesus monkeys. Ovarian recovery and responses were assessed by ultrasonography, serum steroid concentrations, number of oocytes retrieved, and in vitro blastocyst development following IVF. One group underwent a single stimulation regimen with 18 IU rhFSH i.m., followed by 1000 IU hCG, and serum steroid concentrations and ovarian status were determined in the following three menses. Another group was stimulated as before and then allocated into three subgroups; each subgroup was re-stimulated once at the beginning of the ensuing first, second, or third menses. In the final experiment, one group was stimulated with 37.5 IU rhFSH, whereas another group received 18 IU rhFSH. In subsequent cycles, all were re-stimulated twice with 18 IU rhFSH at time intervals of two menstrual cycles (MCs). At the first menses after stimulation, serum progesterone concentrations were significantly higher and the ovaries larger than before stimulation. Monkeys that were re-stimulated at the first menses responded poorly; at the second menses, progesterone concentrations and ovarian size recovered, but the number of oocytes retrieved from re-stimulated monkeys was still significantly reduced. However, animals that were re-stimulated in two MCs later responded well (i.e., percentage of the animals responding, oocytes recovered, and potential for fertilization and blastocyst formation). In conclusion, rhesus monkeys were likely to have similar ovarian responses to repeated stimulation with the same regimen spaced at least two MCs apart
收录类别SCI
资助信息This study was supported by the Chinese Academy of Sciences, KSCX2-YW-R-47, KSCX2-YW-R-089 and Joint Scholar Plan for the Development of Western China; Major State Basic Development Program, 2006CB701505 and 20060102A1070. The authors also thank the German Max-Planck Society for its financial support of the bilateral researchers exchange program.
原文出处200870108.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5627]  
专题昆明动物研究所_生殖与发育生物学
昆明动物研究所_哺乳动物胚胎发育
昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位1.Kunming Primate Research Center and Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan Key Laboratory for Animal Reproduction, Kunming, Yunnan 650223, PR China
2.National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, PR China
3.Graduate School, Chinese Academy of Sciences, Beijing 100039, PR China
4.Leibniz Institute for Zoo and Wildlife Research, PF 601103, 10252 Berlin, Germany
5.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China
6.Life Science and Technology Research Center, Kunming University of Science and Technology, Kunming 650224, PR China
推荐引用方式
GB/T 7714		 Yang S,Shen Y,Niu Y,et al. Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season[J]. THERIOGENOLOGY,2008,70(1):108-114.
APA Yang S.,Shen Y.,Niu Y.,Hildebrandt TB.,JewgenoW K.,...&Ji W[*].(2008).Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season.THERIOGENOLOGY,70(1),108-114.
MLA Yang S,et al."Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season".THERIOGENOLOGY 70.1(2008):108-114.

入库方式： OAI收割

来源：昆明动物研究所

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