Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys
文献类型：期刊论文
| 作者 | Yang S1,2; He X2; Niu Y2; Wang X2; Lu B2; Hildebrandt TB3; Goeritz F3; Jewgenow K3; Zhou Q4; Ji W[*]2 |
| 刊名 | THERIOGENOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 72期号:4页码:560-565 |
| 关键词 | Ovarian follicle Ovarian stimulation Primate Rhesus monkey Ultrasonography |
| ISSN号 | 0093-691X |
| 通讯作者 | wji@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The objective was to study dynamic changes of ovaries in rhesus macaques stimulated by gonadotropins to identify an indicator for predicting ovarian response to stimulation. Twenty-one cycling monkeys were given 36 IU/d recombinant human follicle-stimulating hormone (rhFSH) for 8 d. Animals (n = 17) with >= 5 follicles (>= 3 mm) in their ovaries on Day 9 of ovarian stimulation were deemed good responders, whereas those with a lesser response were poor responders (n = 4). For these two groups, the mean (+/-SD) numbers of oocytes retrieved were 44.3 +/- 21.4 and 11.0 +/- 4.6, respectively. In retrospect, the mean diameters of the ovaries and of the largest follicles, the total number of detectable follicles (diameter >0.5 mm), and serum estradiol concentrations gradually increased during the stimulation period in the good responders but did not increase in the poor responders. Comparing good and poor responders, the number of ovarian follicles >0.5 turn already exhibited a difference (12.9 +/- 6.5 vs. 2.9 +/- 1.3, respectively, P < 0.05) on Day I of stimulation. However, for other end points, differences were not significant until at least Day 5. Moreover, good responders yielded a fivefold higher blastocyst development rate than that of poor responders (P < 0.01). In conclusion, the number of ovarian follicles detected with ultrasonography could be useful to predict the response to FSH stimulation in non-human primates. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by research grants from the Chinese Major State Research Development Program 2007BAI33B05, the Chinese National Basic Research Program 2007CB947701 and 2006CB701505, the Chinese Academy of Sciences KSCX2-YWR-47 and KSCX2-YWR-89, and the Chinese National Science Foundation 30871232. |
| 原文出处 | 2009724560.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5635]  |
| 专题 | 昆明动物研究所_生殖与发育生物学 昆明动物研究所_哺乳动物胚胎发育 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Biotechnology Research Center, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, P.R China 2.Kunming Primate Research Center and Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan Key Laboratory for Animal Reproduction, Kunming, Yunnan 650223, P.R China 3.Leibniz Institute for Zoo and Wildlife Research, PF 601103, 10252 Berlin, Germany 4.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P.R China |
| 推荐引用方式 GB/T 7714 | Yang S,He X,Niu Y,et al. Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys[J]. THERIOGENOLOGY,2009,72(4):560-565. |
| APA | Yang S.,He X.,Niu Y.,Wang X.,Lu B.,...&Ji W[*].(2009).Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys.THERIOGENOLOGY,72(4),560-565. |
| MLA | Yang S,et al."Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys".THERIOGENOLOGY 72.4(2009):560-565. |
入库方式： OAI收割
来源：昆明动物研究所
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