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Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal

文献类型：期刊论文

作者Liu H1; Zhao B2,4; Chen YC3,4; You DW1; Liu R1; Rong MQ1; Ji WZ[*]3; Zheng P2; Lai R[*]1
刊名FASEB journal
出版日期2013
卷号27期号:8页码:3298-3305
关键词MCFD2 pluripotency
通讯作者rlai@mail.kiz.ac.cn ; wji@mail.kiz.ac.cn
合作状况其它
英文摘要Defects in multiple coagulation factor deficiency protein 2 (MCFD2) are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D). MCFD2 was also suggested to play an important role as an autocrine/paracrine factor in maintaining neural stem cell potential. The current work provided direct evidence that both amphibian and human MCFD2 can maintain stem cell pluripotency or stemness of rhesus monkey embryonic stem cells (rESCs) as basic fibroblast growth factor 2 (FGF-2) does. In most cases, MCFD2 had identical effects on stem cells as FGF-2. We investigated the possible mechanism of MCFD2 to support stem cell pluripotency by highlighting the effects of MCFD2 and FGF-2 on several signaling pathways in rESCs, namely MAPK, TGF-beta, Wnt, and Akt, and 3 core transcriptional factors (Oct4, Nanog, and Sox2). In addition, some features of signaling pathways (MAPK and Akt), which are different from human embryonic stem cells (hESCs) and mouse embryonic stem cells (mESCs), are found in rESCs, indicating that primate ESCs have unique signaling mechanisms. These results may shed light on the biological roles of MCFD2, the conserved protein family distributed in both vertebrates and invertebrates. The ability to support stem cell self-renewal may be the general function of the conserved protein family.-Liu, H., Zhao, B., Chen, Y., You, D., Liu, R., Rong, M., Ji, W., Zheng, P., Lai, R. Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal.
收录类别SCI
资助信息This work was supported by the China Ministry of Science and Technology (2010CB529800), the Chinese National Nat- ural Science Foundation (31070701, 31000962, 31025025), the China Ministry of Agriculture (2009ZX08009-159B), the Chinese Academy of Sciences (KSCX2-EW-J-23, KSCX2-EW- R-11), and the Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province. The authors declare no conflict of inter- ests.
语种英语
WOS记录号WOS:000329877600034
公开日期2013-09-25
源URL[http://159.226.149.42:8088/handle/152453/7678]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
昆明动物研究所_遗传资源与进化国家重点实验室
昆明动物研究所_哺乳动物胚胎发育
昆明动物研究所_生殖与发育生物学
昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位1.Key Laboratory of Animal Models and Human Disease Mechanisms
2.State Key Laboratory of Genetic Resources and Evolution
3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
4.Graduate School of Chinese Academy of Sciences, Beijing, China
推荐引用方式
GB/T 7714		 Liu H,Zhao B,Chen YC,et al. Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal[J]. FASEB journal,2013,27(8):3298-3305.
APA Liu H.,Zhao B.,Chen YC.,You DW.,Liu R.,...&Lai R[*].(2013).Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal.FASEB journal,27(8),3298-3305.
MLA Liu H,et al."Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal".FASEB journal 27.8(2013):3298-3305.

入库方式： OAI收割

来源：昆明动物研究所

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