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The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics
文献类型：期刊论文
| 作者 | Yu XJ1,2; Yi ZH1; Gao Z1,2; Qin DD1,2; Zhai YH1; Chen X1; Ou-Yang YC1; Wang ZB1; Zheng P3; Zhu MS4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:X页码:e4887 |
| 通讯作者 | jurriend@helix.nih.gov ; lil@ioz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Maternal effect genes play critical roles in early embryogenesis of model organisms where they have been intensively investigated. However, their molecular function in mammals remains largely unknown. Recently, we identified a subcortical maternal complex (SCMC) that contains four proteins encoded by maternal effect genes (Mater, Filia, Floped and Tle6). Here we report that TLE6, similar to FLOPED and MATER, stabilizes the SCMC and is necessary for cleavage beyond the two-cell stage of development. We document that the SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division of mouse zygotes. We further demonstrate that the SCMC controls formation of the actin cytoskeleton specifically via Cofilin, a key regulator of F-actin assembly. Our results provide molecular insight into the physiological function of TLE6, its interaction with the SCMC and their roles in the symmetric division of the zygote in early mouse development. |
| 收录类别 | SCI |
| 资助信息 | The Li Laboratory was funded by the National Basic Research Program of China (2011CB944501, 2012CB944401), the National Natural Science Foundation of China (30971655), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01010103), and the Hundred Talents Program of Chinese Academy of Sciences. The Dean Laboratory was supported by the Intramural Research Program of the National Institutes of Health, NIDDK, USA. |
| 语种 | 英语 |
| WOS记录号 | WOS:000342983300014 |
| 公开日期 | 2014-11-14 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8167]  |
| 专题 | 昆明动物研究所_哺乳动物胚胎发育 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 2.Institute of Zoology, University of Chinese Academy of Sciences, Beijing 100049, China 3.State Key laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing 210061, China 5.Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892- 8028, USA |
| 推荐引用方式 GB/T 7714 | Yu XJ,Yi ZH,Gao Z,et al. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics[J]. NATURE COMMUNICATIONS,2014,5(X):e4887. |
| APA | Yu XJ.,Yi ZH.,Gao Z.,Qin DD.,Zhai YH.,...&Li L[*].(2014).The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.NATURE COMMUNICATIONS,5(X),e4887. |
| MLA | Yu XJ,et al."The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics".NATURE COMMUNICATIONS 5.X(2014):e4887. |
入库方式： OAI收割
来源：昆明动物研究所
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