Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys
文献类型：期刊论文
| 作者 | Yang S1; He X1; Tang X1; Zhou Q[*]3; Ji W[*]1; Hildebrandt TB2; Jewgenow K2; Goeritz F2 |
| 刊名 | Theriogenology
 |
| 出版日期 | 2007 |
| 卷号 | 67期号:6页码:1194–1201 |
| 关键词 | Rhesus monkey Ovarian follicle Ovarian stimulation rhFSH Embryo development |
| 通讯作者 | yangsh@mail.kiz.ac.cn ; qzhou@ioz.ac.cn ; wji@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The objective was to study the effects of dose of recombinant human follicular stimulating hormone (rhFSH) for ovarian stimulation in rhesus monkeys. Nineteen pubertal and 109 adult female rhesus monkeys were given 37.5, 18, or 9 IU of rhFSH twice-daily for 8 days (total of 600, 300, or 150 IU of rhFSH per cycle, respectively; designated Regimens 1, 2 and 3). Ovarian responses were assessed with ultrasonography, serum concentrations of E2 and FSH, and by in vitro developmental potential (following IVF) of retrieved oocytes. Regimen 1 had more monkeys with very large follicles (diameter>8 mm) than Regimen 2 (P<0.05), which impaired development potential. However, there were no differences between Regimens 1 and 2 in oocyte recovery, whereas Regimen 3 did not elicit superovulation. The developmental potential of embryos obtained from Regimen 2 was higher than that of Regimen 1, as determined by culture to the blastocyst stage in vitro (proportion of blastocysts relative to collected MII oocytes was 55.8% versus 36.8% in pubertal and 63.8% versus 44.2% in adult monkeys; P<0.05 for each), and the results of embryo transfer from Regimen 2 were acceptable. In conclusion, we inferred that the optimal rhFSH dose for ovarian stimulation in rhesus monkeys was a total of 300 IU; this dose should be efficacious for ovarian stimulation as the quality or recovered oocytes was higher and the risk of overstimulation was reduced. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by: Chinese Academy of Sciences, KSCX1-05-02 and Joint Scholar Plan for the Development of Western China; Major State Basic Development Program, 2004CCA01300, 2005AA 219010and2006CB701500;andChinaNationalScience Foundation 30370166. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9636]  |
| 专题 | 昆明动物研究所_哺乳动物胚胎发育 昆明动物研究所_生殖与发育生物学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Kunming Primate Research Center and Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan Key Laboratory for Animal Reproduction, Kunming, Yunnan 650223, PR China 2.Institute for Zoo and Wildlife Research, PF 601103, 10252 Berlin, Germany 3.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China |
| 推荐引用方式 GB/T 7714 | Yang S,He X,Tang X,et al. Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys[J]. Theriogenology,2007,67(6):1194–1201. |
| APA | Yang S.,He X.,Tang X.,Zhou Q[*].,Ji W[*].,...&Goeritz F.(2007).Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys.Theriogenology,67(6),1194–1201. |
| MLA | Yang S,et al."Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys".Theriogenology 67.6(2007):1194–1201. |
入库方式： OAI收割
来源：昆明动物研究所
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