Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice
文献类型：期刊论文
| 作者 | Ruan GP1; Yao X1; Yang SJ2; Wang JX1; Shu F1; Li ZA1; Liu JF1; Pang RQ[*]1; Pan XH[*]1 |
| 刊名 | JOURNAL OF IMMUNOLOGY RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 2014期号:X页码:e530501 |
| 通讯作者 | pangrq2000@aliyun.com ; xinghuapan@aliyun.com |
| 合作状况 | 其它 |
| 英文摘要 | Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Results. After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. Conclusions. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the National Natural Sci- ence Foundation of China (31172170), 973 Projects (2012- CB518106), the Special Project of High-New Technology Industrial Development in Yunnan Province (201204), and the National Support Program (2014BAI01B01) |
| 语种 | 英语 |
| WOS记录号 | WOS:000347830200001 |
| 公开日期 | 2015-02-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8259]  |
| 专题 | 管理、支撑部门_大型仪器中心 |
| 作者单位 | 1.Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China 2.Kunming Biological Diversity Regional Center of Large Apparatus and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Ruan GP,Yao X,Yang SJ,et al. Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014,2014(X):e530501. |
| APA | Ruan GP.,Yao X.,Yang SJ.,Wang JX.,Shu F.,...&Pan XH[*].(2014).Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice.JOURNAL OF IMMUNOLOGY RESEARCH,2014(X),e530501. |
| MLA | Ruan GP,et al."Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice".JOURNAL OF IMMUNOLOGY RESEARCH 2014.X(2014):e530501. |
入库方式： OAI收割
来源：昆明动物研究所
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