Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins
文献类型：期刊论文
| 作者 | Zhao YQ[*]1,2; Wang YJ3; Gao YD4; Li GH1; Huang JF[*]1,5 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:2页码:e0117506 |
| 通讯作者 | zhaoyq@mail.kiz.ac.cn ; huangjf@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | HIV type 1 (HIV-1) is characterized by its rapid genetic evolution, leading to challenges in anti-HIV therapy. However, the sequence variations in HIV-1 proteins are not randomly distributed due to a combination of functional constraints and genetic drift. In this study, we examined patterns of sequence variability for evidence of linked sequence changes (termed as coevolution or covariation) in 15 HIV-1 proteins. It shows that the percentage of charged residues in the coevolving residues is significantly higher than that in all the HIV-1 proteins. Most of the coevolving residues are spatially proximal in the protein structures and tend to form relatively compact and independent units in the tertiary structures, termed as "protein sectors". These protein sectors are closely associated with anti-HIV drug resistance, T cell epitopes, and antibody binding sites. Finally, we explored candidate peptide inhibitors based on the protein sectors. Our results can establish an association between the coevolving residues and molecular functions of HIV-1 proteins, and then provide us with valuable knowledge of pathology of HIV-1 and therapeutics development. |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (Grant No. 31123005), and West Light Foundation of The Chinese Academy of Sciences (awarded to Yuqi Zhao; Grant Nos. Y302401081 and Y302401082). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349545300055 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8277]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 管理、支撑部门_大型仪器中心 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, No.32 Jiaochang Donglu Kunming, 650223 Yunnan, China 2.Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, United States of America 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Kunming Biological Diversity Regional Center of Instruments, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 5.Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Zhao YQ[*],Wang YJ,Gao YD,et al. Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins[J]. PLOS ONE,2015,10(2):e0117506. |
| APA | Zhao YQ[*],Wang YJ,Gao YD,Li GH,&Huang JF[*].(2015).Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins.PLOS ONE,10(2),e0117506. |
| MLA | Zhao YQ[*],et al."Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins".PLOS ONE 10.2(2015):e0117506. |
入库方式： OAI收割
来源：昆明动物研究所
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