A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product
文献类型：期刊论文
| 作者 | Lai R; Liu H; Lee WH; Zhang Y[*] |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2001 |
| 卷号 | 286期号:2页码:259-263 |
| 关键词 | bradykinin amphibian bombinakinin M Bombina maxima cDNA clone kallikrein-kinin system |
| ISSN号 | 0006-291X |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Amphibian skin contains rich bradykinin-related peptides, but the mode of biosynthesis of these peptides is unknown. In the present study, a novel bradykinin-related peptide, termed bombinakinin M, was purified from skin secretions of the Chinese red belly toad Bombina maxima. Its primary sequence was established as DLPKINRKGPRPPGFSPFR that comprises bradykinin extended from its N-terminus by a 10-residue segment DLPKINRKGP. The cDNA structure of bombinakinin M was found to contain a coding region of 624 nucleotides. The encoded precursor of bombinakinin M is composed of a signal peptide, an acidic peptide, six 100% identical copies of a 28-amino-acid peptide unit including bombinakinin M plus a spacer peptide. The sequence of bombinakinin M is preceded by a single basic residue (arginine), which represents the site of cleavage for releasing of mature bombinakinin M. This is the first cDNA cloning of bradykinin-related peptides from amphibian skin. The unique cDNA structure encoding bombinakinin M suggests that the generation modes of bradykinin-related peptides in amphibian skin and in mammalian blood system are different. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants of “STZ98-3-01,” “Western Light Project,” and “Tenth Five Plan” preresearch project from Chi- nese Academy of Sciences and a grant from the Yunnan Science and Technology Commission. |
| 原文出处 | 2001286259.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2461]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物活性蛋白多肽组学 |
| 作者单位 | Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Lai R,Liu H,Lee WH,et al. A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,286(2):259-263. |
| APA | Lai R,Liu H,Lee WH,&Zhang Y[*].(2001).A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,286(2),259-263. |
| MLA | Lai R,et al."A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 286.2(2001):259-263. |
入库方式： OAI收割
来源：昆明动物研究所
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