An anionic antimicrobial peptide from toad Bombina maxima
文献类型：期刊论文
| 作者 | Lai R; Liu H; Lee WH; Zhang Y[*] |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2002 |
| 卷号 | 295期号:4页码:796-799 |
| 关键词 | anionic antimicrobial peptide cationic antimicrobial peptide amphibian Bombina maxima maximin H cDNA clone |
| ISSN号 | 0006-291X |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 英文摘要 | Amphibian skin is a rich resource of antimicrobial peptides like maximins and maximins H from toad Bombina maxima. A novel cDNA clone encoding a precursor protein that comprises maximin 3 and a novel peptide. named maximin H5. was isolated from a skin cDNA library of B. maxima. The predicted primary structure of maximin H5 is ILGPVLGLVSDTLDDVLGIL-NH2,. Containing three aspartate residues and no basic amino acid residues. maximin H5 is characterized by an anionic property. Different from cationic maximin H peptides. only Gram-positive strain Staphylococcus aureus was sensitive to maximin H5. while the other bacteria] and fungal strains tested ere resistant to it. The presence of metal ions. like Zn2+ and Mg2+, did not increase its antimicrobial potency. Maximin H5 represents the first example of potential anionic antimicrobial peptides from amphibians, The results provide the first evidence that. together kith cationic antimicrobial peptides. anionic antimicrobial peptides may also exist naturally as part of the innate defense system. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). |
| 原文出处 | 2002295796.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2465]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物活性蛋白多肽组学 |
| 作者单位 | Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, Yunnan 650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Lai R,Liu H,Lee WH,et al. An anionic antimicrobial peptide from toad Bombina maxima[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2002,295(4):796-799. |
| APA | Lai R,Liu H,Lee WH,&Zhang Y[*].(2002).An anionic antimicrobial peptide from toad Bombina maxima.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,295(4),796-799. |
| MLA | Lai R,et al."An anionic antimicrobial peptide from toad Bombina maxima".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295.4(2002):796-799. |
入库方式： OAI收割
来源：昆明动物研究所
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