Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
文献类型：期刊论文
| 作者 | Lai R1; Zheng YT2; Shen JH1; Liu GJ2; Liu H1; Lee WH1; Tang SZ2; Zhang Y[*]1 |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2002 |
| 卷号 | 23期号:3页码:427-435 |
| 关键词 | amphibian peptide maximin antimicrobial Bombina maxima cDNA sequence HIV |
| ISSN号 | 0196-9781 |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumor cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 were toxic to mice with LD50 values of 8.2 and 4.3 mg/kg, respectively. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides. cDNA sequences revealed that one maximin peptide plus one maximin H peptide derived from a common larger protein. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). |
| 原文出处 | 200223427.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2467]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Department of Viral Immunology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Lai R,Zheng YT,Shen JH,et al. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima[J]. PEPTIDES,2002,23(3):427-435. |
| APA | Lai R.,Zheng YT.,Shen JH.,Liu GJ.,Liu H.,...&Zhang Y[*].(2002).Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.PEPTIDES,23(3),427-435. |
| MLA | Lai R,et al."Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima".PEPTIDES 23.3(2002):427-435. |
入库方式： OAI收割
来源：昆明动物研究所
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