A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima
文献类型：期刊论文
| 作者 | Lai R; Liu H; Lee WH; Zhang Y[*] |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2002 |
| 卷号 | 23期号:3页码:437-442 |
| 关键词 | Bombesin PR-bombesin Amphibian Bombina maxima cDNA Sequence |
| ISSN号 | 0196-9781 |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A novel bombesin-related peptide was isolated from skin secretions of Chinese red belly toad Bombina maxima. Its primary structure was established as pGlu-Lys-Lys-Pro-Pro-Arg-Pro-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH(2.) The amino-terminal (N-terminal) 8-residue segment comprising four prolines and three basic residues is extensively different from bombesins from other Bombina species. The peptide was thus named proline rich bombesin (PR-bombesin). PR-bombesin was found to elicit concentration-dependent contractile effects in the rat stomach strip, with both increased potency and intrinsic activity as compared with those of [Leu(13)]bombesin. Analysis of different bombesin cDNA structures revealed that an 8 to 14- nucleotide fragment replacement in the peptide coding region (TGGGGAAT in the cDNAs of multiple bombesin forms from Bombina orientalis and CACCCCGGCCACCC in the cDNA of PR-bombesin) resulted in an unusual Pro-Pro-Arg-Pro-Pro motif in the N-terminal part of PR-bombesin. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). |
| 原文出处 | 200223437.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2469]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物活性蛋白多肽组学 |
| 作者单位 | Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 Peoples Republic of China |
| 推荐引用方式 GB/T 7714 | Lai R,Liu H,Lee WH,et al. A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima[J]. PEPTIDES,2002,23(3):437-442. |
| APA | Lai R,Liu H,Lee WH,&Zhang Y[*].(2002).A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima.PEPTIDES,23(3),437-442. |
| MLA | Lai R,et al."A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima".PEPTIDES 23.3(2002):437-442. |
入库方式： OAI收割
来源：昆明动物研究所
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