Amphibian tachykinin precursor
文献类型：期刊论文
| 作者 | Li JX1,4; Liu TG1; Xu XQ1,4; Wang X2; Wu M3; Yang HL1; Lai R[*]1,2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 350期号:4页码:983-986 |
| 关键词 | Tachykinin Precursor Amphibian Odorrana grahami |
| ISSN号 | 0006-291X |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The precursor of amphibian tachykinin has not been found although more than 30 tachykinins have been isolated from amphibians since 1964. In this report, two tachykinin-like peptides are identified from the skin secretions of the frog, Odorrana grahami. Their amino acid sequences are DDTEDLANKFIGLM-NH(2) (named tachykinin OG1) and DDASDRAKKFYGLM-NH(2) that is the same with ranamargarin found in Rana margaretae, respectively, with a conserved FXGLM-NH(2) C-terminal consensus motif. By cDNA cloning, their precursors were screened from the skin cDNA library of O. grahami. The precursors are composed of 61 amino acid (aa) residues including a signal peptide followed by an acidic spacer peptide and one copy of mature tachykinin-like peptide. Their overall structure is different from structures of other tachykinin precursors such as human protachykinin 1 precursor containing 143 aa including one copy of substance P (SP) and neurokinin A (NKA), and ascidian tachykinin 1 precursor containing 164 aa including two copies of tachykinin-like peptides. The current results demonstrate that the biosynthesis mode of tachykinins in amphibians is different from other animals. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30570360), Yunnan Natural Science Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). |
| 原文出处 | 2006350983.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2485]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Department of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 210096, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Li JX,Liu TG,Xu XQ,et al. Amphibian tachykinin precursor[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,350(4):983-986. |
| APA | Li JX.,Liu TG.,Xu XQ.,Wang X.,Wu M.,...&Lai R[*].(2006).Amphibian tachykinin precursor.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,350(4),983-986. |
| MLA | Li JX,et al."Amphibian tachykinin precursor".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 350.4(2006):983-986. |
入库方式： OAI收割
来源：昆明动物研究所
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