The first report of kininogen from invertebrates
文献类型：期刊论文
| 作者 | Zhou ZH1,3; Yang HL1,3; Xu XQ1,3; Wang X1; Lai R[*]1,2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 347期号:4页码:1099-1102 |
| 关键词 | Wasp Vespakinin Kininogen Bradykinin Vespa magnifica |
| ISSN号 | 0006-291X |
| 通讯作者 | rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | The hornet possesses highly toxic venom, which is rich in toxin, enzymes, and biologically active peptides. Several bradykinin-like peptides, vespakinins, have been found in wasp venoms since 1970s, but the mode of biosynthesis of these peptides is unknown. In the present study, a vespakinin M was purified from venom of Vespa magnifica. Its primary sequence was established as GRPPGFSP-FRID. The cDNA encoding the vespakinin M was cloned from the cDNA library of V. magnifica venom gland. The cbNA structure of vespakinin M was found to contain a coding region of 168 nucleotides. The encoded precursor of vespakinin M is composed of a signal peptide, an acidic peptide, and a mature peptide of vespakinin M. This is the first kininogen from insects; it is also the first kininogen from invertebrates. The cDNA structure encoding vespakinin M suggests that the generation mode of bradykinin-related peptides in wasp is different from amphibian skin and mammalian blood system. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). |
| 原文出处 | 20063471099.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2487]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, Jiangxi, China |
| 推荐引用方式 GB/T 7714 | Zhou ZH,Yang HL,Xu XQ,et al. The first report of kininogen from invertebrates[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,347(4):1099-1102. |
| APA | Zhou ZH,Yang HL,Xu XQ,Wang X,&Lai R[*].(2006).The first report of kininogen from invertebrates.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,347(4),1099-1102. |
| MLA | Zhou ZH,et al."The first report of kininogen from invertebrates".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 347.4(2006):1099-1102. |
入库方式： OAI收割
来源：昆明动物研究所
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