中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The first report of kininogen from invertebrates

文献类型:期刊论文

作者Zhou ZH1,3; Yang HL1,3; Xu XQ1,3; Wang X1; Lai R[*]1,2
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2006
卷号347期号:4页码:1099-1102
关键词Wasp Vespakinin Kininogen Bradykinin Vespa magnifica
ISSN号0006-291X
通讯作者rlai72@njau.edu.cn
合作状况其它
英文摘要The hornet possesses highly toxic venom, which is rich in toxin, enzymes, and biologically active peptides. Several bradykinin-like peptides, vespakinins, have been found in wasp venoms since 1970s, but the mode of biosynthesis of these peptides is unknown. In the present study, a vespakinin M was purified from venom of Vespa magnifica. Its primary sequence was established as GRPPGFSP-FRID. The cDNA encoding the vespakinin M was cloned from the cDNA library of V. magnifica venom gland. The cbNA structure of vespakinin M was found to contain a coding region of 168 nucleotides. The encoded precursor of vespakinin M is composed of a signal peptide, an acidic peptide, and a mature peptide of vespakinin M. This is the first kininogen from insects; it is also the first kininogen from invertebrates. The cDNA structure encoding vespakinin M suggests that the generation mode of bradykinin-related peptides in wasp is different from amphibian skin and mammalian blood system.
收录类别SCI
资助信息This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422).
原文出处20063471099.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/2487]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
2.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
3.College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, Jiangxi, China
推荐引用方式
GB/T 7714
Zhou ZH,Yang HL,Xu XQ,et al. The first report of kininogen from invertebrates[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,347(4):1099-1102.
APA Zhou ZH,Yang HL,Xu XQ,Wang X,&Lai R[*].(2006).The first report of kininogen from invertebrates.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,347(4),1099-1102.
MLA Zhou ZH,et al."The first report of kininogen from invertebrates".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 347.4(2006):1099-1102.

入库方式: OAI收割

来源:昆明动物研究所

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