Direct antimicrobial activities of PR-bombesin
文献类型:期刊论文
作者 | Li JX1,2; Xu XQ1,2; Yu HN1; Yang HL1; Huang ZX3; Lai R[*]1 |
刊名 | Life Sciences
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出版日期 | 2006 |
卷号 | 78期号:17页码:1953-1956 |
关键词 | PR-bombesin Antimicrobial Neuropeptide Defensive |
ISSN号 | 0024-3205 |
通讯作者 | rlai@mail.kiz.ac.cn |
合作状况 | 其它 |
英文摘要 | PR-bombesin is a bombesin-like peptide derived from the skin of the Chinese red belly toad, Bombina maxima. The 8-residue segment of N-terminal of RP-bombesin, comprising four prolines and three basic residues, is extensively different from other bombesin-like peptides. Since sequence of Pro-Arg-Pro generally plays an important role in the antimicrobial activity of proline-rich antimicrobial peptides, the componential feature of PR-bombesin indicates that it may have antimicrobial activity. In this paper, we presented the first evidence that bombesin-like peptides possess direct antimicrobial activities as some neuropeptides. It was determined by CD spectroscopy that PR-bombesin adopted a combination of random coil and beta-sheet structure, suggesting RP-bombesin is a new member of antimicrobial peptides having beta structure but without disulfide bonds. Current results also supported that PR-bombesin plays a direct defensive role besides its neuro-endocrological functions. |
收录类别 | SCI |
资助信息 | This work was supported by Chinese National Natural Science Foundation (30200044/C01040101) and the Yunnan Science and Technology Commission (2003 C0045M). |
原文出处 | 2006781953.pdf |
语种 | 英语 |
公开日期 | 2010-08-24 |
源URL | [http://159.226.149.42:8088/handle/152453/2491] ![]() |
专题 | 昆明动物研究所_动物毒素室 |
作者单位 | 1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223 China 2.Graduate School of the Chinese Academy of Sciences, Beijing, 100009 China 3.Chemistry Department of Fudan University, Shanghai, 200433 China |
推荐引用方式 GB/T 7714 | Li JX,Xu XQ,Yu HN,et al. Direct antimicrobial activities of PR-bombesin[J]. Life Sciences,2006,78(17):1953-1956. |
APA | Li JX,Xu XQ,Yu HN,Yang HL,Huang ZX,&Lai R[*].(2006).Direct antimicrobial activities of PR-bombesin.Life Sciences,78(17),1953-1956. |
MLA | Li JX,et al."Direct antimicrobial activities of PR-bombesin".Life Sciences 78.17(2006):1953-1956. |
入库方式: OAI收割
来源:昆明动物研究所
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