中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Direct antimicrobial activities of PR-bombesin

文献类型:期刊论文

作者Li JX1,2; Xu XQ1,2; Yu HN1; Yang HL1; Huang ZX3; Lai R[*]1
刊名Life Sciences
出版日期2006
卷号78期号:17页码:1953-1956
关键词PR-bombesin Antimicrobial Neuropeptide Defensive
ISSN号0024-3205
通讯作者rlai@mail.kiz.ac.cn
合作状况其它
英文摘要PR-bombesin is a bombesin-like peptide derived from the skin of the Chinese red belly toad, Bombina maxima. The 8-residue segment of N-terminal of RP-bombesin, comprising four prolines and three basic residues, is extensively different from other bombesin-like peptides. Since sequence of Pro-Arg-Pro generally plays an important role in the antimicrobial activity of proline-rich antimicrobial peptides, the componential feature of PR-bombesin indicates that it may have antimicrobial activity. In this paper, we presented the first evidence that bombesin-like peptides possess direct antimicrobial activities as some neuropeptides. It was determined by CD spectroscopy that PR-bombesin adopted a combination of random coil and beta-sheet structure, suggesting RP-bombesin is a new member of antimicrobial peptides having beta structure but without disulfide bonds. Current results also supported that PR-bombesin plays a direct defensive role besides its neuro-endocrological functions.
收录类别SCI
资助信息This work was supported by Chinese National Natural Science Foundation (30200044/C01040101) and the Yunnan Science and Technology Commission (2003 C0045M).
原文出处2006781953.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/2491]  
专题昆明动物研究所_动物毒素室
作者单位1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223 China
2.Graduate School of the Chinese Academy of Sciences, Beijing, 100009 China
3.Chemistry Department of Fudan University, Shanghai, 200433 China
推荐引用方式
GB/T 7714
Li JX,Xu XQ,Yu HN,et al. Direct antimicrobial activities of PR-bombesin[J]. Life Sciences,2006,78(17):1953-1956.
APA Li JX,Xu XQ,Yu HN,Yang HL,Huang ZX,&Lai R[*].(2006).Direct antimicrobial activities of PR-bombesin.Life Sciences,78(17),1953-1956.
MLA Li JX,et al."Direct antimicrobial activities of PR-bombesin".Life Sciences 78.17(2006):1953-1956.

入库方式: OAI收割

来源:昆明动物研究所

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