A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis
文献类型：期刊论文
| 作者 | Yu D1,2; Sheng ZG1,2; Xu XQ1; Li JX1; Yang HL1; Liu ZG3; Rees HH4; Lai R[*]1 |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:1页码:31-35 |
| 关键词 | Ticks Antimicrobial peptide Ixodes sinensis Salivary gland |
| ISSN号 | 0196-9781 |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A novel antimicrobial peptide named as ixosin was isolated from the salivary glands of the hard tick, Ixodes sinensis, by gel filtration, ion exchange chromatography and reverse-phase high-performance liquid chromatography (RP-HPLC). Its amino acid sequence was determined as GLHKVMREVLGYERNSYKKFFLR by Edman degradation and its molecular weight was 2870.5 analyzed by fast atom bombardment (FAB) mass spectrometry. This is the first antimicrobial peptide from ticks that lacks cysteine in its primary structure. The cDNA encoding ixosin was cloned by cDNA library screening. The predicted protein from the cDNA sequence composed of 79 amino acids including mature ixosin. Purified ixosin exerted its antimicrobial activities against bacteria and fungi. No similarity was found by BLAST search to any database entries and, thus, our findings describe a novel antimicrobial peptide. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30200044/C01040101). |
| 原文出处 | 20062731.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2495]  |
| 专题 | 昆明动物研究所_动物毒素室 |
| 作者单位 | 1.Kunming Institute of Zoology, Chinese Academy of Sciences, Toxicology Department, 32 East Jiao Chang Road, Kunming, Yunnan 650223, PR China 2.Department of Life Science & Technology, Changshu Institute of Technology, Changshu 215500, PR China 3.College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China 4.School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK |
| 推荐引用方式 GB/T 7714 | Yu D,Sheng ZG,Xu XQ,et al. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis[J]. PEPTIDES,2006,27(1):31-35. |
| APA | Yu D.,Sheng ZG.,Xu XQ.,Li JX.,Yang HL.,...&Lai R[*].(2006).A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis.PEPTIDES,27(1),31-35. |
| MLA | Yu D,et al."A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis".PEPTIDES 27.1(2006):31-35. |
入库方式： OAI收割
来源：昆明动物研究所
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