A novel algesic peptide derived from skin secretions of the frog Amolops loloensis
文献类型：期刊论文
| 作者 | Yu HN1; Wang X2; Liu JZ[*]1; Lai R[*]2,3 |
| 刊名 | JOURNAL OF PEPTIDE SCIENCE
 |
| 出版日期 | 2007 |
| 卷号 | 13期号:12页码:798-802 |
| 关键词 | amphibian Amolops loloensis algesic ileum contraction defence |
| ISSN号 | 1075-2617 |
| 通讯作者 | liujingze@mail.hebtu.edu.cn ; rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Several algesic agents including bradykinin and tachykinin have been identified from skin secretions of amphibians. They may act in defensive roles against aggressors. In this study, a novel peptide named Amolos with an amino acid sequence of FLPIVGAKL and isolated from skin secretion of the frog Amolops loloensis, is shown to strengthen nociceptive responses induced by inflammatory factors and strongly inhibit the contraction of isolated ileum. A synthetic peptide based on the sequence obtained showed characterization data identical to those of the isolated material, confirming its structure. These two types of responses seem to be a part of the defensive functions against predators or aggressors. The current results suggest that pharmacological molecules in amphibian skins not only act as innate defense mechanisms against microorganisms but also exert other defensive physiological functions against other aggressors. |
| 收录类别 | SCI |
| 原文出处 | 200713789.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2497]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050016, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Yu HN,Wang X,Liu JZ[*],et al. A novel algesic peptide derived from skin secretions of the frog Amolops loloensis[J]. JOURNAL OF PEPTIDE SCIENCE,2007,13(12):798-802. |
| APA | Yu HN,Wang X,Liu JZ[*],&Lai R[*].(2007).A novel algesic peptide derived from skin secretions of the frog Amolops loloensis.JOURNAL OF PEPTIDE SCIENCE,13(12),798-802. |
| MLA | Yu HN,et al."A novel algesic peptide derived from skin secretions of the frog Amolops loloensis".JOURNAL OF PEPTIDE SCIENCE 13.12(2007):798-802. |
入库方式： OAI收割
来源：昆明动物研究所
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