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An antimicrobial peptide with antimicrobial activity against Helicobacter pylori

文献类型：期刊论文

作者Chen LH1; Li YH2; Li JX3,4; Xu XQ3,4; Lai R[*]1,3; Zou QM[*]2
刊名PEPTIDES
出版日期2007
卷号28期号:8页码:1527-1531
关键词amphibian antimicrobial peptide Odorrana grahami Helicobacter pylori
ISSN号0196-9781
通讯作者rlai@mail.kiz.ac.cn ; qmzou@mail.tmmu.com.cn
合作状况其它
英文摘要An antimicrobial peptide named odorranain-HP was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLRASSVWGRKYYVDLAGCAKA. By BLAST search, odorranain-HP had similarity to antimicrobial peptide odorranain-W1 but it has a different GLLR N-terminus. The cDNA encoding odorranain-HP was cloned from the cDNA library of the skin of O. grahami. This peptide showed antimicrobial activities against tested microorganisms. Interestingly, odorranain-HP could exert antimicrobial capability against Helicobacter pylori, along with its antimicrobial activities similar to odorranain-W1. This is the first report of naturally occurring peptide with anti-H. pylori activity from amphibian skins.
收录类别SCI
资助信息This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences.
原文出处2007281527.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/2503]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
2.Department of Clinical Immunology and Clinical Microbiology, Third Military Medical University, Chongqing 400038, China
3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式
GB/T 7714		 Chen LH,Li YH,Li JX,et al. An antimicrobial peptide with antimicrobial activity against Helicobacter pylori[J]. PEPTIDES,2007,28(8):1527-1531.
APA Chen LH,Li YH,Li JX,Xu XQ,Lai R[*],&Zou QM[*].(2007).An antimicrobial peptide with antimicrobial activity against Helicobacter pylori.PEPTIDES,28(8),1527-1531.
MLA Chen LH,et al."An antimicrobial peptide with antimicrobial activity against Helicobacter pylori".PEPTIDES 28.8(2007):1527-1531.

入库方式： OAI收割

来源：昆明动物研究所

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